Determination of Hexamethylene Diisocyanate-Based Isocyanates in Spray-Painting Operations. Part 2. Comparison of High Performance Liquid Chromatography with Capillary Zone Electrophoresis

Details

• Personal Author:
  Carlton G ; England E ; Rudzinski WE ; Yin J
• Description:
  A capillary zone electrophoresis (CZE) approach was developed for the determination of hexamethylene diisocyanate (HDI) monomer and HDI-based oligomers. A comparison of CZE with high performance liquid chromatography (HPLC) indicates that the CZE separation completely isolates isocyanates from excess solvent, derivatizing reagent and pigment while offering a fivefold increase in sensitivity. The CZE approach allows for the quantification of HDI monomer and oligomer within a 1 min time window under the run conditions selected. For the determination of HDI-based oligomer, provided that the relative response with respect to HDI monomer is calculated, there is no significant difference (p < 0.05, n = 10) in the isocyanate air concentration when using either HPLC or CZE. The results are significant because they indicate that CZE has advantages for the determination of both HDI-based oligomer and HDI monomer generated during spray-painting operations. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Chromatography Environmental Monitoring Isocyanates Occupational Health Paint Particulate Matter Safety
• Keywords:
  Airborne-particles Chromatographic-analysis Cyanates Exposure-assessment Paint-spraying Painting Paints Pollutants Samplers Sampling Sampling-methods Spray-painting

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• ISSN:
  0003-2654
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  119-123
• Volume:
  124
• Issue:
  2
• NIOSHTIC Number:
  nn:20031349
• Citation:
  Analyst 1999 Feb; 124(2):119-123
• Contact Point Address:
  Department of Chemistry, Southwest Texas State University, San Marcos 78666
• CAS Registry Number:
  Hexamethylene diisocyanate (CAS RN 822-06-0)
• Federal Fiscal Year:
  1999
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  Texas State University - San Marcos
• Peer Reviewed:
  True
• Start Date:
  19950501
• Source Full Name:
  Analyst
• End Date:
  19970430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5ac21284f05699f239998ef342bc8bb4f43e4ff10fd2d19275365b71db611428e9199581c36e2a244bc7360841467e175b774765405ce35fbe8de735eb91f7e
• Download URL:
  https://stacks.cdc.gov/view/cdc/191617/cdc_191617_DS1.pdf
• File Type:
  [PDF - 124.66 KB ]