Association of Genetic Variations in VEGF, EGF and ICAM-1 Genes with Progressive Massive Fibrosis

Details

• Personal Author:
  Fluharty K ; Johnson VJ ; Kashon ML ; Luster MI ; Vallyathan V ; Yucesoy, Berran
• Description:
  Vascular endothelial growth factor (VEGF), epithelial growth factor (EGF) and intercellular adhesion molecule-1 (ICAM-1) play a critical role in the pathogenesis of pulmonary fibrosis by mediating angiogenesis, growth promotion, collagen degradation and leukocyte accumulation. Several single nucleotide polymorphisms (SNPs) have been described in these genes, some of which have been reported to be associated with different expression levels. Based on this, the influence of functional genetic variations in VEGF, EGF and ICAM-1 genes on the development of progressive massive fibrosis (PMF) was investigated. VEGF +405, EGF +61 and ICAM-1 +241 single nucleotide polymorphisms were examined in lung autopsy tissues from 691 miners with and without PMF using a case-control study design. While no significant differences in the distribution of genotypes between PMF and control groups were detected, a significant gene-gene interaction was found between VEGF +405 and ICAM-1 +241 variants (p<0.05). These data suggest that VEGF +405 and ICAM-1 +241 variants may play at least a minor role in individual susceptibility to PMF. [Description provided by NIOSH]
• Subjects:
  Case Reports Fibrosis Genetics Lung Mining Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Case-studies Genes Lung-fibrosis Lung-tissue Miners Pathogenesis Pathogenicity Pulmonary-system-disorders
• ISSN:
  1546-3222
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  3
• NIOSHTIC Number:
  nn:20031252
• Citation:
  Proc Am Thorac Soc 2006 Apr; 3(Abstracts):A504
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the American Thoracic Society
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a34cae95e34b78ad554cbc403eb85c9c9b980e0f1955c2ea178dcbb86e207c25f6a9b9a3ef81715e52be39e759b148768fecf7e84ee56646b8b2a01d602e4fa8
• Download URL:
  https://stacks.cdc.gov/view/cdc/191556/cdc_191556_DS1.pdf
• File Type:
  [PDF - 76.07 KB ]