Decreases in CD8+T, Naive (CD4+CD45RA+) T, and B (CD19+) Lymphocytes by Exposure to Manganese Fume

Details

• Personal Author:
  Araki S ; Kim D-S ; Nakata A ; Park H-C ; Park J-T ; Park S-H ; Yokoyama K
• Description:
  To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders mainly exposed to Mn fume with blood Mn (BMn) concentrations of 0.6-2.3 (mean 1.4) µg/dl and 21 healthy controls working in the same factory (BMn concentrations: 0.7 to 1.7, mean 1.1 µg/dl). The workers engaged in welding for 6 to 36 (mean 17) yr. All the study subjects were divided into 3 equally sized groups (n=14 for each group) according to BMn concentrations. Numbers of CD8+ T, total T (CD3+), B (CD19+), and total lymphocytes were significantly lower in high-BMn group than those in low-BMn group; the numbers of CD8+ T lymphocytes were significantly lower in moderate-BMn group compared to low-BMn group. After adjusting for age and smoking, significant inverse correlations between BMn concentrations and CD4+CD45RA+ T, CD4+ T, CD8+ T, CD3+ T, and total lymphocytes were found. We conclude that T lymphocytes, especially CD8+ and CD4+CD45RA+ T lymphocytes, as well as CD19+ B lymphocytes are affected by exposure to Mn fume. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Blood Environmental Monitoring Manganese Occupational Exposure Occupational Health Safety Welding
• Keywords:
  Exposure-assessment Exposure-levels Fumes Fumigants Immune-system Immunotoxins Lymphocytes Manganese-compounds Occupational-exposure Occupational-health Welders Welders-lung

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• ISSN:
  0019-8366
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  44
• Issue:
  4
• NIOSHTIC Number:
  nn:20031220
• Citation:
  Ind Health 2006 Oct; 44(4):592-597
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Work Environment and Workforce: Organization of Work
• Peer Reviewed:
  True
• Source Full Name:
  Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:488fa727155ecb6e9f1824fde4a799d9e71ace6d130840c9b469c75840287d06a6b007d88381731b9b1efba96d4370e1dcacb91435853c57e89276f6dc15a9fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/191533/cdc_191533_DS1.pdf
• File Type:
  [PDF - 33.21 KB ]