Validation of the NES2 in Patients with Neurologic Disorders

Details

• Personal Author:
  Diamond R ; Eisen E ; Feldman RG ; Krengel M ; Letz R ; Lindem K ; Wegman, David H. ; White RF
• Description:
  Performance on the Neurobehavioral Evaluation System (NES) has been demonstrated to be affected by exposure to a variety of neurotoxicants. However, the relation of NES subtests to CNS function has not yet been documented in patients diagnosed with neurologic disorders known to implicate specific brain substrates. A validation study of the NES2 was carried out in patients with multiple sclerosis (MS) and Parkinson's disease (PD), disorders exhibiting neuropathology at loci (white matter in MS, basal ganglia in PD) believed to be the sites of action of several known neurotoxicants. The results indicated that performance on certain NES2 subtests was affected in expected ways in both types of patients. However, performance on many more subtests was impaired, relative to controls, in MS than in PD. The relative insensitivity to PD suggests that expansion and refinement of the battery are required if it is to serve well in detecting the effects of toxicants in subjects without frank physical symptoms. These are the goals of a new version of the instrument currently under development (NES3). [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Diseases Exposure-assessment Nervous-system-disorders Neurological-diseases Neurological-reactions Neurological-system Neurotoxic-effects Neurotoxicity Neurotoxicology Neurotoxins
• ISSN:
  0892-0362
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  441-448
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:20031096
• Citation:
  Neurotoxicol Teratol 1996 Jul-Aug; 18(4):441-448
• Contact Point Address:
  Roberta F. White, Boston Department of Veterans Administration Medical Center, Boston Environmental Hazards Center and the Neurology and Psychology Services, 150 South Huntington Avenue 116B-4, Boston, MA 02130
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Neurotoxic Disorders
• Performing Organization:
  Boston University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19900701
• Source Full Name:
  Neurotoxicology and Teratology
• End Date:
  19980630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82c7b322e5709f1892c649e579e55b2fd9dd197cbb9ff92ddb3f036a16afe51014651a0949c3f885456b8f9ac8e53fd4866b1ef4535ae7f5871d95220c974a5d
• Download URL:
  https://stacks.cdc.gov/view/cdc/191452/cdc_191452_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]