Evoked-Potential Thresholds and Cubic Distortion Product Otoacoustic Emissions in the Chinchilla Following Carboplatin Treatment and Noise Exposure

Details

• Personal Author:
  Ahroon WA ; Aldrich LG ; Hamernik RP ; Jock BM ; Johnson AR ; Petriello KL
• Description:
  Twenty-two chinchillas were given either a single intraperitoneal (i.p.) or intravenous (i.v.) injection (50 or 75 mg/kg) of Paraplatin, an asymptotic threshold shift-producing noise or a combination of the drug and noise in series. Auditory evoked potential (pure-tone) audiograms and cubic distortion product otoacoustic emissions were obtained on each animal before and after treatment, and the sensory epithelium of the cochlea was evaluated using the surface preparation method. Anatomical analysis indicated that the carboplatin alone caused relatively severe but scattered losses of inner hair cells throughout most of the cochlea which were dependent on dose and administration route. The outer sensory cell population remained essentially intact. In animals that had up to 40% scattered losses of only inner hair cells, evoked potential thresholds were near normal and the emission functions either were normal or showed an enhanced output. The severe losses of inner hair cells produced by the drug had no effect on the threshold shift dynamics produced by a five-day uninterrupted noise exposure. In general, there was not a consistent relation between the emission data and both the permanent threshold shift and outer hair cell losses. [Description provided by NIOSH]
• Subjects:
  Animals Hearing Loss Hearing Loss, Noise-Induced Noise Occupational Health Safety
• Keywords:
  Acoustics Animal-studies Auditory-system Author Keywords: Hearing Loss Carboplatin Diseases Hearing-loss Models Noise-exposure Noise-induced-hearing-loss Otoacoustic Emission

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• ISSN:
  0378-5955
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179-190
• Volume:
  96
• Issue:
  1
• NIOSHTIC Number:
  nn:20031090
• Citation:
  Hear Res 1996 Jul; 96(1-2):179-190
• Contact Point Address:
  Auditory Research Laboratory, 107 Beaumont Hall, State University of New York, Plattsburgh, NY 12901, USA
• Email:
  ahroonwa@splava.cc.plattsburgh.edu
• CAS Registry Number:
  Carboplatin (CAS RN 41575-94-4)
• Federal Fiscal Year:
  1996
• Performing Organization:
  Plattsburgh State University, New York
• Peer Reviewed:
  True
• Start Date:
  19860301
• Source Full Name:
  Hearing Research
• End Date:
  20130514
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:848180507d1fc102f8dece3b4863ec4dc8097e6e85528225c724b87c04d1685b870bbf368f3a754b2a3cb8ffc87bea7609c07a9dc1c750c2faa201b1ed5da37f
• Download URL:
  https://stacks.cdc.gov/view/cdc/191446/cdc_191446_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]