The Upper Midwest Health Study: A Case-Control Study of Primary Intracranial Gliomas in Farm and Rural Residents

Details

• Personal Author:
  Butler MA ; Calvert, Geoffrey M. ; Carreón T ; Connally LB ; Davis-King KE ; Heineman EF ; Lu J ; Mandel JS ; Morton RF ; Reding DJ ; Rosenman, Kenneth D. ; Ruder, Avima M. ; Schulte, Paul A. ; Wall D ; Ward, Elizabeth M. ; Waters MA ; Zivkovich Z ; Butler MA ; Calvert, Geoffrey M. ; Carreón T ; Connally LB ; Davis-King KE ; Heineman EF ; Lu J ; Mandel JS ; Morton RF ; Reding DJ ; Rosenman, Kenneth D. ; Ruder, Avima M. ; Schulte, Paul A. ; Wall D ; Ward, Elizabeth M. ; Waters MA ; Zivkovich Z
• Description:
  Since several studies indicated that farmers and agricultural workers had an excess risk of brain cancer, the National Institute for Occupational Safety and Health initiated the Upper Midwest Health Study to examine risk of intracranial glioma in the non-metropolitan population. This population-based, case-control study evaluated associations between gliomas and rural and farm exposures among adults (ages 18 to 80) in four upper Midwestern states (Iowa, Michigan, Minnesota, Wisconsin). At diagnosis/selection, participants lived in non-metropolitan counties where the largest population center had fewer than 250,000 residents. Cases were diagnosed 1 January 1995 through 31 January 1997. Over 90% of 873 eligible ascertained cases and over 70% of 1670 eligible controls consented to participate. Participants and nonparticipants, evaluated for "critical questions" on main and refusant questionnaires, differed significantly in farming and occupational experience, ethnicity, education, and lifestyle. The 1175 controls were more likely than the 798 cases to have reported ever drinking alcohol (77% vs. 73%, adjusted odds ratio (OR) 0.73, 95% confidence interval (CI) 0.59-0.92) and having had panoramic dental x-rays (34% vs. 29%, OR 0.75, CI 0.61-0.92). Controls spent a greater percentage of their lives in non-metropolitan counties (78% vs. 75%, OR 0.81, CI 0.67-1.09). Among ever-farmers, controls were more likely to have had exposure to farm insecticides (57% vs. 50%, OR 0.75, CI 0.59-0.95) and farm animals (96% vs. 91%, OR 0.48, CI 0.25-0.90). Moving to a farm as an adolescent (ages 11 to 20) vs. as an adult was associated with a greater risk of glioma (OR 1.96, CI 1.13-3.39). In our study sample, farm or rural residence and summary farm exposures were associated with decreased glioma risk. However, nonparticipation by never-farming eligible controls could have affected results. Comparisons of farm chemical exposures may clarify associations between farming and glioma that others have reported. [Description provided by NIOSH]
• Subjects:
  Age Factors Agriculture Demography Epidemiology Farmers Insecticides Occupational Health Race Factors Safety Sex Characteristics
• Keywords:
  Age-factors Agricultural-chemicals Agricultural-workers Agrochemicals Author Keywords: Agricultural Workers Case-control Study Demographic-characteristics Glioma Pesticides Pesticides-and-agricultural-chemicals Proxy Racial-factors Sex-factors Study Design

  More +
• ISSN:
  1074-7583
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Georgia ; Iowa ; Michigan ; Minnesota ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  255-274
• Volume:
  12
• Issue:
  4
• NIOSHTIC Number:
  nn:20031076
• Citation:
  J Agric Saf Health 2006 Nov; 12(4):255-274
• Contact Point Address:
  Avima M. Ruder, National Institute for Occupational Safety and Health, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  amr2@cdc.gov
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Agricultural Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:827e948cbae367de843b0aa95cea7f17f53cb96ed72d00976f57b991bb9902ef3c4cb63bb4c873d09fe7d471c2bff651edb1e1304d6cfe1b122e7a06f0fe0b0e
• Download URL:
  https://stacks.cdc.gov/view/cdc/191440/cdc_191440_DS1.pdf
• File Type:
  [PDF - 235.70 KB ]