Hydrocarbon-Based Weapons Maintenance Compounds Produce Evidence of Contact Hypersensitivity in Balb/C Mice

Details

• Personal Author:
  Arfsten DP ; Azadi S ; Butterworth LF ; Meade BJ
• Description:
  Unprotected dermal contact with weapons maintenance materials is highly probable during cleaning and maintenance of firearms. Several weapons maintenance materials of interest to the Department of Defense were evaluated for their irritating and sensitizing potential in a modified local lymph node assay (LLNA). Female BALB/c mice (n = 5) were topically exposed to Break-Free CLP, Royco 634, TW-25B, MC-25, or MC-2500. All compounds tested produced a positive response for irritancy and lymphocyte proliferation. Break-Free CLP and Royco 634 produced the greatest dermal irritation and highest LLNA stimulation index. Phenotyping of draining lymph node cells from animals treated with Break-Free CLP suggest that this material induces T-cell-mediated contact sensitization (Type IV hypersensitivity) in mice. These findings support the recommendation that persons handling or using weapons maintenance materials should protect their skin from repeated contact by wearing appropriate personal protective equipment. [Description provided by NIOSH]
• Subjects:
  Animals Dermatitis Hydrocarbons Hypersensitivity Irritants Laboratories Occupational Health Personal Protective Equipment Safety Skin Skin Diseases

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• Keywords:
  Animal-studies Dermatology Dermatosis Laboratory-animals Personal-protective-equipment Skin-irritants
• ISSN:
  1556-9527
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  185-194
• Volume:
  25
• Issue:
  3
• NIOSHTIC Number:
  nn:20031045
• Citation:
  Cutan Ocul Toxicol 2006 Jan; 25(3):185-194
• Email:
  darfsten@dlj0ndsl.med.navy.mil
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Peer Reviewed:
  True
• Source Full Name:
  Cutaneous and Ocular Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c7d8bf152e6c694263dbd3c71d653fa2f8bbdfc8f428acbbcdabe6aec29e3af7e4774595a29a851ce7e845851b2166cff8888cf5c77495d40e0251172cf82d50
• Download URL:
  https://stacks.cdc.gov/view/cdc/191433/cdc_191433_DS1.pdf
• File Type:
  [PDF - 344.79 KB ]