Transcellular Route of Diffusion Through Stratum Corneum: Results from Finite Element Models

Details

• Personal Author:
  Barbero AM ; Frasch, H. Fredrick
• Description:
  Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (tlag) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n=27) of hydrophilic compounds was compiled from the literature. Transcellular and lateral lipid diffusion pathways were modeled within a brick-and-mortar geometry representing fully hydrated human SC. Modeled tlag's for the lipid pathway are too brief to account for the experimental quantities, whereas the transcellular pathway with preferential corneocyte partitioning does account for them. Measured tlag's are highly correlated (p<0.0001) with the compound's octanol-water partition coefficient, supporting the hypothesis of an aqueous-lipid partition mechanism in the permeation of hydrophilic compounds. The importance of the lag time for identifying the diffusion pathway is demonstrated. [Description provided by NIOSH]
• Subjects:
  Coal Coal Mining Engineering Geology Mining Occupational Health Safety Software
• Keywords:
  Diffusion-analysis Mathematical-models Models Pharmaceuticals Skin-absorption
• ISSN:
  0022-3549
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  95
• Issue:
  10
• NIOSHTIC Number:
  nn:20031040
• Citation:
  J Pharm Sci 2006 Oct; 95(10):2186-2194
• Contact Point Address:
  H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505
• Email:
  HFrasch@cdc.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Pharmaceutical Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d17fd756419bf0a3877d0c18ffb0e546c593184fe0078fd627833a045905050c5811effb9263a697e10a02d6f7d67f7e44ef6eb0a973f009e22fabb6f6bfc0b
• Download URL:
  https://stacks.cdc.gov/view/cdc/191431/cdc_191431_DS1.pdf
• File Type:
  [PDF - 149.06 KB ]