Strawberries Inhibit Cancer Cell Proliferation

Details

• Personal Author:
  Bowman L ; Ding M ; Lewers K ; Wang SO
• Description:
  Representatives of three species of strawberries (Fragaria virginiana, F chiloensis and F x ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO, -OH , (1)0(2) and O(2)), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in 'CFRA 0982', 'JP 95-1-1', NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in 'AlIstar'. There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO, -OH, (1)0(2) and O(2), respectively. These results suggest that antioxidants, specifically their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful for cancer prevention. [Description provided by NIOSH]
• Subjects:
  Antineoplastic Agents Antioxidants Free Radicals Neoplasms Occupational Health Safety
• Keywords:
  Antineoplastic-agents Cancer Disease-prevention Free-radicals
• ISSN:
  0018-5345
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• Issue:
  4
• NIOSHTIC Number:
  nn:20030997
• Citation:
  HortScience 2006 Jul; 41(4):1082
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  False
• Source Full Name:
  HortScience
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f121b6f9f15c20eb772ec483faddf2b40e9bf5f1bc3c4f31a9b3cb6b1da801b039d69b838bc69be56bb69ac62cc3f268130178ba5446eb4a221c7ac939007ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/191403/cdc_191403_DS1.pdf
• File Type:
  [PDF - 217.21 KB ]