Pulmonary Fibrosis

Details

• Personal Author:
  Luster MI ; Yucesoy, Berran
• Description:
  With the identification of the DNA sequence of the human genome and increasing data on polymorphisms, genetic epidemiology offers a powerful approach to the identification of genetic variants that influence susceptibility to many common diseases. Although the pathogenesis of pulmonary fibrosis remains incompletely understood, identification and understanding the role of genetic risk factors helps provide novel insights into the pathophysiology of the disease and identify molecular regulators of inflammatory and fibrotic processes. The use of new high-throughput genotyping technology, statistical genetic methods and robust association study designs which considers population stratification, sample size, intermediate phenotypes, linkage disequilibrium, and gene-gene/gene environment interactions, will help lead to a better understanding of fibrotic mechanisms in the lung and identification of high-risk groups. This information may also aid in the development of novel therapeutic targets at a molecular level. [Description provided by NIOSH]
• Subjects:
  Genetics Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Fibrogenesis Fibrogenicity Genes Genotoxicity Pulmonary-system-disorders Respiratory-system-disorders
• ISBN:
  0849336198
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  351-362
• NIOSHTIC Number:
  nn:20030863
• Citation:
  Cytokine gene polymorphisms in multifactorial conditions. Vandenbroeck K, ed. Boca Raton, FL: CRC Press, 2006 Jun; :351-362
• Editor(s):
  Vandenbroeck K
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Cytokine gene polymorphisms in multifactorial conditions
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:15b83efbfbe32a455632ca18b389370b0b23a0dbeff932e1e19d8bbba8b56c036cae51363bb8ef326e6ef943502b4b385fdb3b3e1504eacd7f92dfba71c11a4c
• Download URL:
  https://stacks.cdc.gov/view/cdc/191328/cdc_191328_DS1.pdf
• File Type:
  [PDF - 3.70 MB ]