Mortality in Polychlorinated Biphenyl Exposed Electrical Capacitor Manufacturing Workers

Details

• Personal Author:
  Davis-King K ; Hein M ; Laber P ; Nilsen N ; Prince M ; Ruder A ; Schnorr, Teresa M. ; Ward E ; Waters M ; Whelan, Elizabeth A.
• Description:
  Polychlorinated biphenyl (PCB) exposure has been associated with cancer risk. Vital status for 14,458 workers with >/= 90 days potential PCB exposure 1939-77 at two capacitor manufacturing plants was verified through 1998 to examine cancer mortality and excess liver and rectal cancer reported in a subcohort. Standardized mortality ratios (SMRs, U.S. rates) and Poisson regression rate ratios (RRs) were assayed; a job exposure matrix estimated PCB exposure. Liver and prostate cancer mortality was not elevated (liver, 21 deaths, SMR 0.9, 95% confidence interval (CI) 0.6-1.4; prostate, 34 deaths, SMR 1.0, CI 0.7-1.5), but rose with low to high cumulative exposure (liver RRs: 1.7, CI 0.3-10.3; 3.0, CI 0.6-15.4; 4.2, CI 0.9-19.8, p for trend 0.07; prostate RRs: 1.5, CI 0.4-5.6; 2.8, CI 0.8-9.6; 6.1, CI 2.0-18.2, p for trend 0.0001). Stomach cancer mortality among men (n = 24, SMR 1.5, CI 1.0-2.3) rose with cumulative exposure. Mortality from myeloma (n = 28, SMR 1.9, CI 1.2=2.7), intestinal cancer among women (n = 67, SMR 1.3, CI 1.0=1.7), and rectal cancer (n = 21, SMR 1.1, CI 0.7=1.7) were elevated but not clearly related to exposure. Ovarian cancer mortality, elevated among long term workers, rose with cumulative exposure. This study cannot associate intestinal or rectal cancer with PCB exposure but supports prior reports of elevated liver cancer mortality, is the first occupational cohort study to show a strong exposure-response relationship between PCBs and prostate cancer mortality, and suggests that myeloma, ovarian cancer, and male stomach cancer mortality may be related to PCB exposure. [Description provided by NIOSH]
• Subjects:
  Accident Prevention Accidents Engineering Geology Mining Occupational Health Safety Software
• Keywords:
  Cancer Cancer-rates Liver-cancer Mortality-data Mortality-rates Occupational-exposure Polychlorinated-biphenyls Prostate-cancer Pulmonary-system-disorders Risk-analysis Risk-factors Stomach-cancer Workers

  More +
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  163
• Issue:
  11
• NIOSHTIC Number:
  nn:20030789
• Citation:
  Am J Epidemiol 2006 Jun; 163(11)(Suppl):S158
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Epidemiology. Abstracts of the 2nd North American Congress of Epidemiology, June 21-24, 2006, Seattle, Washington
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa2cb287cb05d4fbd51902cc261f76a524ed97559a677cdb0c993715e91e41b0afe7d54c1e7b301ef912d7ae944d4af75db839f4c1ee4cca9dfcff62a73d1e0b
• Download URL:
  https://stacks.cdc.gov/view/cdc/191287/cdc_191287_DS1.pdf
• File Type:
  [PDF - 380.65 KB ]