Dietary Vitamin A and Prevalence of Bronchial Metaplasia in Asbestos-Exposed Workers

Details

• Personal Author:
  Cullen MR ; Mayne ST ; Redlich CA
• Description:
  The purpose of this investigation was to examine the association between dietary intake of vitamin A in the form of retinol and provitamin A carotenoids and the prevalence of bronchial squamous metaplasia in a sample of asbestos workers from an industrial clinic. Bronchial biopsies were obtained from 49 asbestos workers. Pulmonary function testing was done and in-person interviews were conducted to estimate dietary intake of retinol and provitamin A carotenoids, tobacco exposure, and asbestos exposure. Results indicated that workers with metaplasia reported consuming a significantly lower intake of total vitamin A [2000 retinol equivalents (RE)/d] than did subjects without metaplasia (2710 RE/d, P = 0.02). Logistic regression analyses showed that higher intakes of retinol [odds ratio (OR): 0.31; 95% CI: 0.04, 2.44], provitamin A carotenoids (OR: 0.31; 95% CI: 0.03, 2.84), and total vitamin A (OR: 0.29; 95% CI: 0.03, 2.49) were associated with a nonsignificant reduction in the OR for metaplasia (highest quartile compared with lowest quartile, adjusted ORs). Current smoking (OR: 5.25; 95% CI: 0.50, 55.1) and former smoking (OR: 2.95; 95% CI: 0.31, 28.1) were associated with a nonsignificant increase in the OR for bronchial metaplasia compared with never smoking. Greater airway obstruction [decreased forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)] was associated with an increased OR for metaplasia (OR: 2.86; 95% CI: 1.09, 7.69). These results suggest that a higher (ie, above the median) intake of vitamin A from foods decreases the risk of bronchial metaplasia in workers occupationally exposed to asbestos. [Description provided by NIOSH]
• Subjects:
  Asbestos Environmental Monitoring Inorganic Chemicals Lung Occupational Exposure Occupational Health Respiratory Function Tests Respiratory System Risk Assessment Risk Factors Safety Smokers Surveys And Questionnaires

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• Keywords:
  Asbestosis Exposure-assessment Exposure-levels Occupational-exposure Pulmonary-function Pulmonary-function-tests Questionnaires Risk-analysis Risk-factors Sampling Sampling-methods Smoking Vitamins

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• ISSN:
  0002-9165
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  68
• Issue:
  3
• NIOSHTIC Number:
  nn:20030573
• Citation:
  Am J Clin Nutr 1998 Sep; 68(3):630-635
• Email:
  Susan.Mayne@Yale.Edu
• Federal Fiscal Year:
  1998
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  The American Journal of Clinical Nutrition
• End Date:
  19931231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a373e54efc58d8de28c8047587da5a43cbb27e6d1dd389f407010037ec2069856c9b9660988d84acb1947b8b5431d3ca6b6c2fc3355e90dc201c46128be02277
• Download URL:
  https://stacks.cdc.gov/view/cdc/191131/cdc_191131_DS1.pdf
• File Type:
  [PDF - 118.77 KB ]