Simultaneous Gas Chromatographic-Mass Spectrometric Quantitation of the Alkylbenzene Inert Components, Pesticide Manufacturing By-Products and Active Ingredient in Two Malathion Formulations

Details

• Personal Author:
  Lin Y-W ; Que Hee SS ; Lin Y-W ; Que Hee SS
• Description:
  A rapid, reliable and effective method for direct determination of the inert components, manufacturing by-products of the pesticide, and active ingredient in two malathion formulations has been established using capillary gas chromatography-mass spectrometry (GC-MS) with the internal standard method. The C2-, C3-, and C4-alkylbenzenes, the major pesticide manufacturing by-products (O,O,S-trimethylthionophosphate, diethyl maleate and O,O,O-trimethylthionophosphate), and malathion were resolved, and quantified in the same chromatogram. Structural identification was based on MS total ion current data, comparison of GC retention times with those of authentic standards, and retention indices. O,O,S-Trimethylthionophosphate was quantified at 3.57 +/- 0.31% (w/w) in one malathion formulation. While the malathion contents were within specifications for both formulations, the total alkylbenzene contents were not. [Description provided by NIOSH]
• Subjects:
  Benzene Insecticides Mass Spectrometry Occupational Health Organophosphates Safety
• Keywords:
  Benzenes Gas-chromatography Mass-spectrometry Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticide-industry Pesticides Pesticides-and-agricultural-chemicals
• ISSN:
  0021-9673
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  181-186
• Volume:
  814
• Issue:
  1
• NIOSHTIC Number:
  nn:20030566
• Citation:
  J Chromatogr A 1998 Jul; 814(1-2):181-186
• Contact Point Address:
  Department of Environmental Health Sciences and UCLA Center for Occupational and Environmental Health, UCLA School of Public Health, 10833 Le Conte Avenue, Los Angeles, CA 90095-1772, USA
• CAS Registry Number:
  Malathion (CAS RN 121-75-5) ; Malathion (CAS RN 121-75-5)
• Federal Fiscal Year:
  1998
• NORA Priority Area:
  Research Tools and Approaches: Intervention Effectiveness Research ; Research Tools and Approaches: Intervention Effectiveness Research
• Performing Organization:
  University of California, School of Public Health, Department of Environmental Health Sciences, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19920930
• Source Full Name:
  Journal of Chromatography A
• End Date:
  19951130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b28403f94484868044c01d9e51f11c37bcd386fb820e1583510b8b8c8e463e0cc7ad54fad58e26e156369e4193639a4d5f3d011ab2d7253987ef5794d3d1c3eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/191129/cdc_191129_DS1.pdf
• File Type:
  [PDF - 72.04 KB ]