In Utero Exposure to Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) and Neurodevelopment Among Young Mexican American Children

Details

• Personal Author:
  Barr DB ; Bradman A ; Eskenazi B ; Fenster L ; Jewell NP ; Johnson C ; Marks AR
• Description:
  We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. Participants from the Center for the Health Assessment of Mothers and Children of Salinas study, a birth cohort study, included 360 singletons with maternal serum measures of p,p'-DDT, o,p'-DDT, and p,p'-DDE. Psychomotor development and mental development were assessed with the Bayley Scales of Infant Development at 6, 12, and 24 months. We found a approximately 2-point decrease in Psychomotor Developmental Index scores with each 10-fold increase in p,p'-DDT levels at 6 and 12 months (but not 24 months) and p,p'-DDE levels at 6 months only. We found no association with mental development at 6 months but a 2- to 3-point decrease in Mental Developmental Index scores for p,p'-DDT and o,p'-DDT at 12 and 24 months, corresponding to 7- to 10-point decreases across the exposure range. Even when mothers had substantial exposure, breastfeeding was usually associated positively with Bayley scale scores. Prenatal exposure to DDT, and to a lesser extent DDE, was associated with neurodevelopmental delays during early childhood, although breastfeeding was found to be beneficial even among women with high levels of exposure. Countries considering the use of DDT should weigh its benefit in eradicating malaria against the negative associations found in this first report on DDT and human neurodevelopment. [Description provided by NIOSH]
• Subjects:
  Agriculture Demography Farmers Occupational Health Race Factors Safety
• Keywords:
  Agricultural-industry Agricultural-workers Children Demographic-characteristics In-utero-exposure Prenatal-exposure Racial-factors
• ISSN:
  0031-4005
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  233-241
• Volume:
  118
• Issue:
  1
• NIOSHTIC Number:
  nn:20030518
• Citation:
  Pediatrics 2006 Jul; 118(1):233-241
• Contact Point Address:
  Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720-7380, USA
• Email:
  eskenazi@berkeley.edu
• CAS Registry Number:
  DDT (CAS RN 50-29-3)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Pediatrics
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bd872e4eb55830c93f9b12b67459b9975d71a0c639f6759debd58d6257c2c70275c30d6a34b1bb744bc518505005ce1b78c58880b1f0c0cd86f6b76581a2fe50
• Download URL:
  https://stacks.cdc.gov/view/cdc/191101/cdc_191101_DS1.pdf
• File Type:
  [PDF - 414.24 KB ]