Mortality of Workers Employed in Shoe Manufacturing: An Update

Details

• Personal Author:
  Hein, Misty J. ; Lehman EJ
• Description:
  In the late 1970s, the National Institute for Occupational Safety and Health identified two shoe manufacturing facilities where workers experienced relatively "pure" exposures to toluene. A mortality study was conducted through December 31, 1982. An original study did not detect elevated leukemia mortality but did detect increased lung cancer mortality. The present study is an update of the mortality of the original cohort. The study cohort consisted of workers employed 1 month or more between 1940 and 1979 at two Ohio shoe manufacturing plants. Vital status was ascertained through December 31, 1999. Seven thousand eight hundred twenty eight workers, contributing 300,777 person years, were available for analysis. An excess of lung cancer deaths persisted with additional years of follow-up (SMR = 1.36, 95% confidence interval (CI) = 1.19-1.54). Trend tests did not indicate a positive trend between lung cancer risk and duration of employment. Mortality from leukemia was not significantly elevated in the updated analysis. Results indicate a possible association between lung cancer mortality and exposure to chronic, low-levels of organic solvents. Although the strength of this conclusion was weakened by the lack of increasing lung cancer risk in relation to duration of employment, other studies have supported this association. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Solvents Toluene Xylenes

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• Keywords:
  Cancer Chronic-exposure Employee-exposure Employee-health Employees Lung-cancer Mortality-data Mortality-rates Occupational-exposure Occupational-health Organic-solvents Pulmonary-system-disorders Risk-analysis Risk-factors Shoe-manufacturing Toluenes Worker-health Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  49
• Issue:
  7
• NIOSHTIC Number:
  nn:20030502
• Citation:
  Am J Ind Med 2006 Jul; 49(7):535-546
• Contact Point Address:
  Everett J. Lehman, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-13, Cincinnati, OH 45226
• Email:
  ELehman@cdc.gov
• CAS Registry Number:
  Toluene (CAS RN 108-88-3) ; Xylene (CAS RN 1330-20-7)
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f488849eb8b8b429609d340db4bf5e24b105e840c71d9a47995b239c691e4bd4271de702437afe1420ccaba442c6047d38687a013da8b2ab197b28bc50b3c03c
• Download URL:
  https://stacks.cdc.gov/view/cdc/191087/cdc_191087_DS1.pdf
• File Type:
  [PDF - 148.64 KB ]