Cooperativity Between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)-kappaB: Requirement of Ras/Mitogen-Activated Protein Kinases in the Activation of NF-kappaB by Oxidants

Details

• Personal Author:
  Barnett M ; Becker A ; Beckman J ; Calvert, Geoffrey M. ; Das R ; Male D ; Mehler LN ; Morrissey B ; Sievert J ; Thomsen, Catherine
• Description:
  Emergency responders are among the first to arrive at a pesticide-related release event. Magnitude, severity, and risk factor information on acute pesticide poisoning among those workers is needed. Survey data collected from the SENSOR-Pesticides, CDPR and HSEES programs between 1993 and 2002 from 21 states were reviewed. Acute occupational pesticide-related illness incidence rates for each category of emergency responder were calculated, as were incidence rate ratios (IRR) among emergency responders compared to all other workers employed in non-agricultural industries. A total of 291 cases were identified. Firefighters accounted for 111 cases (38%), law enforcement officers for 104 cases (36%), emergency medical technicians for 34 cases (12%), and 42 cases (14%) were unspecified emergency responders. Among the 200 cases with information on activity responsible for exposure, most were exposed while performing activities related to a pesticide release event (84%) and not involving patient care, while the remainder involved exposure to pesticide-contaminated patients. A majority of cases were exposed to insecticides (51%). Most had low severity illnesses (90%). The incidence rate was highest for firefighters (39.1/million) and law enforcement officers (26.6/million). The IRRs were also elevated for these professions (firefighters, IRR = 2.67; law enforcement officers, IRR = 1.69). The findings suggest the need for greater efforts to prevent acute occupational pesticide-related illness among emergency responders. [Description provided by NIOSH]
• Subjects:
  Agriculture Emergencies Emergency Responders Firefighters Hazardous Substances Insecticides Law Enforcement Occupational Exposure Occupational Health Poisoning Risk Assessment Risk Factors Safety

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• Keywords:
  Agricultural-chemicals Emergency-responders Emergency-response Fire-fighters Health-hazards Law-enforcement Law-enforcement-workers Occupational-exposure Occupational-hazards Occupational-health Pesticides Pesticides-and-agricultural-chemicals Poisons Police-officers Risk-analysis Risk-factors Surveillance-programs Worker-health Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  383-393
• Volume:
  49
• Issue:
  5
• NIOSHTIC Number:
  nn:20030104
• Citation:
  Am J Ind Med 2006 May; 49(5):383-393
• Contact Point Address:
  Geoffrey M. Calvert, National Institute for Occupational Safety & Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226
• Email:
  jac6@cdc.gov
• Federal Fiscal Year:
  2006
• Performing Organization:
  Texas Department of State Health Services
• Peer Reviewed:
  True
• Start Date:
  20020930
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d0269a09d64a9c8baf07a2f65403b0c29cc061cc47ccbe0fd2b197613b828946ad85b1946e41db37c9c4cbbb6333760ef6adeafe00bee10a58eaf267d6f8e43
• Download URL:
  https://stacks.cdc.gov/view/cdc/190928/cdc_190928_DS1.pdf
• File Type:
  [PDF - 133.29 KB ]