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Induction of Secondary Apoptosis, Inflammation, and Lung Fibrosis After Intratracheal Instillation of Apoptotic Cells in Rats

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  • Personal Author:
  • Description:
    An aerosol generation facility has been characterized to produce well-defined silver nanoparticles for use as a test aerosol when evaluating instrument response to different particle morphologies within a range of sizes. The generator consists of two in-series laminar tube furnaces to produce and subsequently sinter particles, and is capable of generating spherical or agglomerated fractal-like silver particles, with corresponding projected surface (two-dimensional) fractal dimensions from 1.58 to 1.94. The morphologies of generated particles as well as size distributions at different sintering temperatures were characterized using a transmission electron microscope (TEM) and a scanning mobility particle sizer (SMPS). Mean diameters measured were significantly reduced for sintering temperatures from 100 to 300 degrees C , but showed little variation for sintering temperatures above 500 degrees C . TEM analysis indicated that this phenomenon was caused by sintering, followed by partial and complete coalescence of fractal-like agglomerates into spheres. Agglomerate restructuring from classical completely sintered agglomerates (500 degrees C) to spherical particles (700 degrees C) did not lead to a change in the particle mobility size distribution. The temperature at which complete sintering occurred was higher than that predicted by theory, but was in reasonable agreement with previously published experimental data. For monodisperse particles in the size range from 20 to 100 nm, a simple exponential model related sintering temperature to the diameter of coalesced spherical particles. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0021-8502
  • Document Type:
    Text
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Division:
    DART - Division of Applied Research and Technology
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    452-470
  • Volume:
    37
  • Issue:
    4
  • NIOSHTIC Number:
    nn:20030098
  • Citation:
    J Aerosol Sci 2006 Apr; 37(4):452-470
  • Contact Point Address:
    Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA
  • Email:
    bik5@cdc.gov
  • CAS Registry Number:
    Silver (CAS RN 7440-22-4)
  • Federal Fiscal Year:
    2006
  • Peer Reviewed:
    True
  • Source Full Name:
    Journal of Aerosol Science
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:f183204c4fe7c576dad6c4880b980b46b2a762eceacb05841916d4afe2fb21e423dac80a5ccbd48b5937be27174f5e6bd9cb233309014024c5950c76092499fd
  • Download URL:
  • File Type:
    Filetype[PDF - 538.89 KB ]
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