Occupational Exposures and Movement Abnormalities Among Japanese-American Men: The Honolulu-Asia Aging Study

Details

• Personal Author:
  Burchfiel CM ; Charles LE ; Fekedulegn D ; Kashon ML ; Petrovitch H ; Ross GW ; Sanderson, Wayne T.
• Description:
  The authors analyzed data on 1,049 men aged 71-93 years (excluding those with prevalent Parkinson's disease and stroke) from the Honolulu Heart Program (1965-1968) and the Honolulu-Asia Aging Study (1991-1999) to determine whether occupational exposures to pesticides, solvents, metals, manganese, and mercury during middle age were associated with 14 movement abnormalities 25 years later. Analyses of variance and multivariate logistic regression were used to assess associations of interest. After adjustment for age, BMI, cognitive functioning, smoking, alcohol drinking, education, and physical activity, there was a positive association between abnormal 'facial expression' and the highest exposure to metals [odds ratio (OR) = 2.62; 95% confidence interval (CI) = 1.35-5.11; trend, p = 0.02], and the highest exposure to mercury (OR = 1.91; 95% CI = 1.04-3.49; trend, p = 0.03). Age was positively associated with all movement abnormalities, and cognitive function, body mass index and physical activity were inversely associated with most movement abnormalities. Higher exposure to any metal, and specifically mercury, was associated with abnormal facial expression. [Description provided by NIOSH]
• Subjects:
  Age Factors Demography Insecticides Manganese Men Mercury Metals Occupational Exposure Occupational Health Race Factors Safety Sex Characteristics Solvents

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• Keywords:
  Age-factors Demographic-characteristics Manganese-compounds Mercury-compounds Metal-compounds Occupational-exposure Pesticides Racial-factors Sex-factors
• ISSN:
  0251-5350
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Hawaii ; Iowa ; OSHA Region 3 ; OSHA Region 7 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  130-139
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:20030068
• Citation:
  Neuroepidemiology 2006 Apr; 26(3):130-139
• Email:
  lcharles@cdc.gov
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5) ; Mercury (CAS RN 7439-97-6)
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  Neuroepidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5680766d1366cc35dc70c7d09dae6767d0b6515bccd774fcfd6740603d4f3c5af1f874cdedff13a06dbfd56da16543940acf14ea5c53e7268659fefa9f27dc25
• Download URL:
  https://stacks.cdc.gov/view/cdc/190904/cdc_190904_DS1.pdf
• File Type:
  [PDF - 89.97 KB ]