Strict Avoidance of Exposure to Natural Rubber Latex (NRL) Glove Products Is Associated with Longitudinal Reduction in Percutaneous Reactivity to NAL and Hev B Proteins

Details

• Personal Author:
  Amin HS ; Arif SAM ; Bernstein DI ; Biagini, Raymond E. ; Hamilton, Robert G. ; Kalra H ; Yeang HY
• Description:
  Longitudinal effects of avoidance of powdered NRL glove exposure on puncture skin test (PST) reactivity to non-ammoniated latex (NAL) and purified native allergens (Hev b) have not been assessed. Endpoint percutaneous threshold concentrations (EPCs) in 34 of 62 health care workers (HCWs; mean age = 45 yrs, range 26-73 yrs) first evaluated in 2000 were re-evaluated in 2005 by PST with NAL, native Hevs bl, b2, b3, b4, b6.01, b7.01 and b13 and recombinant Hev b5. A period of 56.2 + 2.2 months (mean + SD) elapsed between the two evaluations. Reduced NRL sensitization was defined on retesting as a conversion to a negative NAL PST or a 2-log increase in NAL EPC over the period 2000-2005. In 2005, 7/34 (21 %) of HCWs had lost all PST sensitivity to NAL and all Hev b proteins; 26/34 HCWs showed reduced NRL sensitization from 2000. Significant increases in median EPCs for NAL (Wilcoxon, p<0.001) and reductions in the proportions of HCWs with positive PSTs to Hevs b2, b5, b6.01, and b7.01 were observed over the period from 2000-2005 (McNemar's, p<0.05 to p<0.001). An association with reduced NRL sensitization was observed in those individuals who changed jobs to one without latex glove exposure (Phi coefficient, 0.652, p<0.002). Personal avoidance of exposure in NRL sensitized HCWs produces detectable long term reduction or loss of skin sensitivity to NAL and Hev b allergens. [Description provided by NIOSH]
• Subjects:
  Health Personnel Hypersensitivity Immune System Occupational Health Personal Protective Equipment Safety Skin Skin Diseases
• Keywords:
  Allergens Allergies Gloves Health-care-personnel Immunology Proteins Sensitization Skin-disorders Skin-irritants
• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  2
• NIOSHTIC Number:
  nn:20029979
• Citation:
  J Allergy Clin Immunol 2006 Feb; 117(2)(Suppl 1):S86
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d43dc16f78c9cadc5acf80a6a1898563b63842ea2d8a67406071517e910ae1fd5066d1cfa43840f6ebd9bb5e0c08e1185f21559d341bf0988173489f4bb33206
• Download URL:
  https://stacks.cdc.gov/view/cdc/190842/cdc_190842_DS1.pdf
• File Type:
  [PDF - 146.36 KB ]