Dose and Airflow Dependence of Benzyl Alcohol Disposition on Skin

Details

• Personal Author:
  Bhatt V ; Kasting GB ; Miller MA
• Description:
  The penetration of benzyl alcohol (BA) through split-thickness cadaver skin was measured in nonoccluded Franz cells placed in a fume hood. BA, dissolved in a small volume of ethanol and spiked with (14)C radiolabel, was applied to skin at nine doses ranging from 0.9 to 10600 microg/cm(2). The percentage of radioactivity penetrated after 24 h increased gradually with dose, ranging from 19.8 +/- 2.9% at the lowest dose to 29.2 +/- 3.0% at the highest. Less than 4% of the radioactivity was retained in the tissue at 24 h; the remainder was considered to be evaporated. These data and those from a previous study were analyzed in terms of a finite dose diffusion/evaporation model. The analysis showed that the increase in BA absorption with dose was consistent with a threefold increase in BA diffusivity in the stratum corneum, as its concentration increased from tracer levels to saturation. The variable diffusivity model was able to describe the combined observations from the two studies to within an rms error of 4.2% of dose. A method of estimating the diffusion model parameters independently of the experiment was found to yield good agreement with the experimentally-derived values at low and moderate doses. [Description provided by NIOSH]
• Subjects:
  Air Movements Environmental Monitoring Occupational Health Safety Skin Skin Absorption
• Keywords:
  Air-flow Dose-response Exposure-assessment Exposure-levels Mathematical-models Models Skin-absorption
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  281-291
• Volume:
  95
• Issue:
  2
• NIOSHTIC Number:
  nn:20029953
• Citation:
  J Pharm Sci 2006 Feb; 95(2):281-291
• Email:
  Gerald.Kasting@uc.edu
• CAS Registry Number:
  Benzyl alcohol (CAS RN 100-51-6)
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67b21e2e87a73fa1bcc665e316ea90d43015b7ca4c315adb73016be1e20029df4a02d196a63b53bfddaf7fb523ebc17a71fc4dfca8c2862c02cd18060e50d60a
• Download URL:
  https://stacks.cdc.gov/view/cdc/190824/cdc_190824_DS1.pdf
• File Type:
  [PDF - 156.88 KB ]