Mycobacterium immunogenum Causes Hypersensitivity Pneumonitis-Like Pathology in Mice

Details

• Personal Author:
  Donnelly K ; Galdanes K ; Gordon T ; Lewis, Dick ; Nadziejko C
• Description:
  A surprising number of cases of hypersensitivity pneumonitis have been observed at work sites employing automotive machinists. Because hypersensitivity pneumonitis is not typically associated with exposure to metalworking fluid aerosols, this study examined whether Mycobacterium immunogenum (M. immunogenum), a rapidly growing mycobacterium isolated from several affected work sites, could induce hypersensitivity pneumonitis in mice. Hypersensitivity pneumonitis-like histologic changes occurred in mice treated with heat-killed and lysed M. immunogenum. These lung lesions were characterized by peribronchial and perivascular lymphohistiocytic inflammation and noncaseating granulomas in the parenchyma. The pathologic changes observed in mice instilled with M. immunogenum-contaminated used metalworking fluid were indistinguishable from those observed with M. immunogenum alone. The role of genetic factors in M. immunogenum-induced lung lesions was examined by comparison of the response of eight inbred strains of mice. The observed immunologic changes in the lung were significantly greater in C57Bl/6, 129, and BALB/c mice than in the other strains, suggesting that genetic factor(s) contribute to the susceptibility of workers exposed to M. immunogenum-contaminated metalworking fluid aerosols. Thus, these studies provide indirect evidence that M. immunogenum is an unrecognized class of microorganisms capable of causing hypersensitivity pneumonitis and plays a role in the outbreaks of hypersensitivity pneumonitis in automotive plants. [Description provided by NIOSH]
• Subjects:
  Animals Automobiles Genetics Hypersensitivity Laboratories Lung Diseases Manufacturing And Industrial Facilities Microbiology Occupational Health Safety
• Keywords:
  Animal-studies Automotive-industry Genetic-factors Laboratory-animals Lung-disorders Machinists Microorganisms
• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  449-456
• Volume:
  18
• Issue:
  6
• NIOSHTIC Number:
  nn:20029934
• Citation:
  Inhal Toxicol 2006 May; 18(6):449-456
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  New York University
• Peer Reviewed:
  True
• Start Date:
  19930901
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20050929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3074e069e4929503c4240560c961773983bf7269743313657a6649afe185398e3f367cc03f886a4665e0760327f92b84c5e7b1883b8bf81d5abf84a3f5901af3
• Download URL:
  https://stacks.cdc.gov/view/cdc/190811/cdc_190811_DS1.pdf
• File Type:
  [PDF - 1.89 MB ]