Inert Multiple Membrane-Coated Fibers Predict Dermal Absorption of Chemicals from Mixtures

Details

• Personal Author:
  Baynes RE ; Monteiro-Riviere NA ; Riviere JE ; Xia X
• Description:
  Skin absorption of compounds from chemical mixtures is affected by many factors including chemical-chemical, chemical-vehicle, chemical-skin and vehicle-skin interactions; with the rate-limiting process primarily being interactions with the stratum corneum. To address this, we have developed a multiple membrane-coated fiber (MCF) approach that unlike in vitro skin systems, has the advantages of relatively high throughput. Three diverse MCFs [polydimethylsiloxane (PDMS, lipophilic), polyacrylate (PA, polarizable) and CarboWax (wax, polar)] were selected to simulate the array of molecular interactions existing in the skin/chemical mixture systems. Skin permeability coefficient (log kp) of a set of 16 diverse compounds from chemical mixtures (water, water-ethanol, water surfactant) were measured by in vitro flow through diffusion experiments and membrane/chemical mixture partition coefficients (log KMCF/Mix) were determined. Concentrations of all chemicals were assayed using GC-MS. Multiple regression analysis was used to define equations linking log kp to log KMCF/Mix for the three MCFs across the three vehicle systems. Significant correlation equations were defined for each vehicle exposure: water - R2=0.96; 50% ethanol - R2=0.91; and 1% SLS - R2=0.86. Differences in equations across vehicles probably reflect mixture-skin interactions. These studies demonstrate that dermal absorption of a diverse series of compounds can be estimated from data collected in three inert fibers which reflect the physicochemical diversity of interactions seen when chemicals partition into the stratum corneum. [Description provided by NIOSH]
• Subjects:
  Chemistry Occupational Health Safety Skin Skin Absorption
• Keywords:
  Chemical-analysis In-vitro-studies In-vivo-studies Skin-absorption
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  90
• Issue:
  1
• NIOSHTIC Number:
  nn:20029877
• Citation:
  Toxicologist 2006 Mar; 90(1):171
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20010601
• Source Full Name:
  The Toxicologist. Society of Toxicology 45th Annual Meeting and ToxExpo, March 5-9, 2006, San Diego, California
• End Date:
  20100331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:efd21e1f2e0bc8eec9e0ced0e420bf2a753b2232dbfa2a759e6e19b566de34220c7c7b43cadba6c42d6570515c08c736109931b339f50186793af51836ca2c56
• Download URL:
  https://stacks.cdc.gov/view/cdc/190771/cdc_190771_DS1.pdf
• File Type:
  [PDF - 152.71 KB ]