Predicting Exposure Conditions That Facilitate the Potentiation of Noise-Induced Hearing Loss by Carbon Monoxide

Details

• Personal Author:
  Chen GD ; Fechter LD ; Larabee J ; Rao D
• Description:
  Hearing loss is the most common occupational disease in the United States, with noise serving as the presumed causative agent in most instances. This investigation characterizes the exposure conditions that facilitate the potentiation of noise-induced hearing loss (NIHL) by carbon monoxide (CO). Auditory function was compared in rats exposed 4 weeks earlier to noise alone, CO alone, combined exposure, and air in the exposure chamber. This interval between exposure and auditory threshold assessment was selected to permit recovery of temporary threshold shifts. The compound action potential (CAP) threshold evoked by pure tone stimuli was used as a measure of auditory sensitivity. The no adverse effect level (NOAEL) with respect to potentiation of NIHL was found to be 300 ppm CO. Potentiation of NIHL by CO increases linearly as CO concentration increases between 500 -1500 ppm. Benchmark dose software (version 1. 1B) published by the U.S. EPA National Center for Environmental Assessment was employed to determine a benchmark concentration of CO that produced either a 5-dB potentiation of NIHL or an increase in auditory threshold equivalent to 10% of the effect of noise alone. The lower bound for these benchmark concentrations were 320 and 194 ppm CO, respectively. Unlike CO dose, the relationship between noise severity and potentiation of NIHL by CO shows a nonlinear relationship. The greatest potentiation was observed at moderate noise exposures (100 dB, 2-h, octave band-limited noise, or OBN) that produce limited permanent threshold shifts. Repeated exposures to 95-dB noise for 2-h periods in combination with 1200 ppm CO also yielded potentiation of NIHL, though such effects were not observed following a single combined exposure. These results underscore the potential risk of hearing loss from combined exposure to noise and CO, and the risks associated with repeated exposure. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Chemistry, Analytic Hearing Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Noise, Occupational Occupational Health Safety

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• Keywords:
  Analytical Chemistry Analytical Methods Animal Studies Automotive Emissions Chemical Analysis Dose Response Exposure Assessment Hearing Disorders Hearing Protection Hearing Tests Laboratory Animals Mechanics Noise Exposure Noise Induced Hearing Loss Ototoxicity Statistical Analysis Synergistic Effects Toll Booth Workers Tunnel Workers

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Oklahoma ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  315-323
• Volume:
  58
• Issue:
  2
• NIOSHTIC Number:
  nn:20029817
• Citation:
  Toxicol Sci 2000 Dec; 58(2):315-323
• Contact Point Address:
  The University of Oklahoma, Health Sciences Center, College of Pharmacy, P.O. Box 26901, Oklahoma City, OK 73190
• Email:
  fechter@ouhsc.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Hearing Loss
• Performing Organization:
  University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
• Peer Reviewed:
  True
• Start Date:
  19970901
• Source Full Name:
  Toxicological Sciences
• End Date:
  20000831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71d21917fb3d8c6eabfce42bf90e81dd2434596bc1203e6d36354820728c9cc25c68f0519f86a6c59e1016910e6ce1e25337cf05cae18c0a230d40ea0995ff61
• Download URL:
  https://stacks.cdc.gov/view/cdc/190724/cdc_190724_DS1.pdf
• File Type:
  [PDF - 136.51 KB ]