A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research

Details

• Personal Author:
  Bromberg P ; Enright, Paul L. ; Geller A ; Koren H ; Martinez F ; Selgrade M ; Shore S ; Sly P ; Weiss S ; Weissman, David N. ; Yeatts K
• Description:
  Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma), and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA "Asthma Research Strategy" document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of "susceptibility factors" that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Biological Factors Diet Environmental Exposure Environmental Health Epidemiology Genetics Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Adult Air-contamination Author Keywords: Asthma Biological-factors Childhood Disease-prevention Elderly Environmental-exposure Hygiene Hypothesis Incidence Indoor-air-pollution Indoor-environmental-quality In Utero Lung-cells Lung-disease Lung-function Obesity Occupational Asthma Pulmonary-system-disorders Respiratory-system-disorders Smoking Susceptibility Windows Of Exposure And Age

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  114
• Issue:
  4
• NIOSHTIC Number:
  nn:20029744
• Citation:
  Environ Health Perspect 2006 Apr; 114(4):634-640
• Contact Point Address:
  Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine and Department of Epidemiology, School of Public Health, Campus Box #7310, CEMALB, HSD Facility, 104 Mason Farm Rd., University of North Carolina-Chapel Hill, NC 27599-7310
• Email:
  Karin_Yeatts@unc.edu
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61ccc646c02979f3378e7775f77769236c65cdc7e60d5cf0deaf5f7278fd3d66e687308650320b5e07ece6fe924ba2f86c7d0028a9d06a40808bba6af65d8f0f
• Download URL:
  https://stacks.cdc.gov/view/cdc/190663/cdc_190663_DS1.pdf
• File Type:
  [PDF - 137.48 KB ]