Chemical Carcinogenesis

Details

• Personal Author:
  Harris CC ; Weston A
• Description:
  Human chemical carcinogenesis is a multistage process that results from exposures, usually in the form of complex chemical mixtures, often encountered in the environment or through our lifestyle and diet (Table 14-1). A prime example is tobacco smoke, which can cause cancers at multiple sites, including the lung, bladder, head, and neck. Although most chemical carcinogens do not react directly with intracellular components, they are activated to carcinogenic and mutagenic electrophiles by metabolic processes evolutionary designed to rid the body of toxins and to modify endogenous compounds. Electrophilic chemical species are naturally attracted to nucleophiles like DNA and protein, and through covalent bonding to deoxyribonucleic acid (DNA) genetic damage results. Once internalized, carcinogens are subject to competing processes of metabolic activation and detoxication, although some chemical species can act directly. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chemistry DNA Energy Metabolism Environmental Exposure Epidemiology Mutagens Neoplasms Occupational Health Safety
• Keywords:
  Cancer Carcinogenesis Carcinogenicity Chemical-composition DNA-damage Environmental-exposure Metabolism Mutagenesis Mutagenicity Tumorigenesis Tumorigens Tumors

  More +
• ISBN:
  9781550093070
• Publisher:
  B C Decker Inc.
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-13
• NIOSHTIC Number:
  nn:20029420
• Citation:
  Cancer medicine, 7th edition. Hamilton, Ontario, Canada: B C Decker Inc, 2006 Feb; :1-13
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  Cancer medicine, 7th edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c951327e0dc06a98238d47dd3c84b28a48ca00837dd6ec23c3c13a6174cff1c171f3c6d849c576bb1e44dcf358dde2efe0b15ae8dcab8a4cdbc5ef3cd9f5793
• Download URL:
  https://stacks.cdc.gov/view/cdc/190405/cdc_190405_DS1.pdf
• File Type:
  [PDF - 2.96 MB ]