Urinary Hexane Diamine to Assess Respiratory Exposure to Hexamethylene Diisocyanate Aerosol: A Human Inhalation Study

Details

• Personal Author:
  Berode M ; Boeniger, Mark F. ; Holm CT ; Liu Y ; Redlich CA ; Slade MD ; Stowe MH ; Walsh FX
• Description:
  The use of urinary hexane diamine (HDA) as a biomarker to assess human respiratory exposure to hexamethylene diisocyanate (HDI) aerosol was evaluated. Twenty-three auto body shop workers were exposed to HDI biuret aerosol for two hours using a closed exposure apparatus. HDI exposures were quantified using both a direct-reading instrument and a treated-filter method. Urine samples collected at baseline, immediately post exposure, and every four to five hours for up to 20 hours were analyzed for HDA using gas chromatography and mass spectrometry. Mean urinary HDA (microg/g creatinine) sharply increased from the baseline value of 0.7 to 18.1 immediately post exposure and decreased rapidly to 4.7, 1.9 and 1.1, respectively, at 4, 9, and 18 hours post exposure. Considerable individual variability was found. Urinary HDA can assess acute respiratory exposure to HDI aerosol, but may have limited use as a biomarker of exposure in the workplace. [Description provided by NIOSH]
• Subjects:
  Automobiles Biomarkers Epidemiology Hexanes Isocyanates Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Automobile-repair-shops Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders Statistical-analysis
• ISSN:
  1077-3525
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  262-271
• Volume:
  10
• Issue:
  3
• NIOSHTIC Number:
  nn:20029300
• Citation:
  Int J Occup Environ Health 2004 Jul; 10(3):262-271
• Contact Point Address:
  Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510-2283
• Email:
  youcheng.liu@yale.edu
• CAS Registry Number:
  Biuret (CAS RN 108-19-0) ; Hexamethylene diisocyanate (CAS RN 822-06-0)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19970901
• Source Full Name:
  International Journal of Occupational and Environmental Health
• End Date:
  20020831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:777241bed70e809594444f7a7f0b65f9ec673ef261929dcec544d7b9e8828ffb6ff3bc5ffde355fd12e02157bce1c2732b6bd3153be663bdfccd79796071ada7
• Download URL:
  https://stacks.cdc.gov/view/cdc/190320/cdc_190320_DS1.pdf
• File Type:
  [PDF - 1.50 MB ]