A Longitudinal Observation of Early Pulmonary Responses to Cotton Dust

Details

• Personal Author:
  Christiani, David C. ; Dai H-L ; Pan L-D ; Sun B-X ; Wang X-R ; Zhang H-X
• Description:
  To examine early adverse pulmonary effects of exposure to cotton dust, and to identify potential risk factors, including atopy for pulmonary responses to cotton dust. Spirometry, methacholine challenge testing, and questionnaire; performed among 101 non-smoking newly hired textile workers at baseline (prior to starting work), and at 3, 12, and 18 months after starting work. Concentrations of airborne cotton dust in various work areas were measured at each follow up survey using vertical elutriators. The incidence of non-specific respiratory symptoms was 8% at three months, then diminished afterwards. Substantial acute cross shift drops in FEV(1) at each follow up survey, and longitudinal declines in FVC and FEV(1) after 12 months of exposure were observed. Airway responsiveness to methacholine increased with follow up time, and was more pronounced among atopics. Increasing airway responsiveness was strongly correlated with cross shift drops in FEV(1). In addition, one or more respiratory symptoms at three months was significantly, and pre-existing atopy marginally significantly, associated with cross shift drops in FEV(1) after adjusting for other covariates and confounders. Results suggest that non-specific respiratory symptoms, decreasing lung function, and increasing airway responsiveness are early pulmonary responses to cotton dust. In addition, the occurrence of respiratory symptoms and increasing airway responsiveness, as well as atopy, may be important predictors for acute changes in lung function among cotton textile workers. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Lung Occupational Exposure Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Textile Industry

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• Keywords:
  Airborne-dusts Airborne-particles Cotton-dust Dust-particles Dusts Lung-function Occupational-exposure Pulmonary-system-disorders Respiratory-system-disorders Risk-analysis Risk-factors Spirometry Textile-workers Workers

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  115-121
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20029262
• Citation:
  Occup Environ Med 2003 Feb; 60(2):115-121
• Contact Point Address:
  Dr D C Christiani, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
• Email:
  dchris@hohp.harvard.edu
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard University
• Peer Reviewed:
  True
• Start Date:
  19870701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:278a595cb3b5d84b2ea8d4b26c2e1af9b178648c63bdbc08a3d39a32002fb78aa7560f7f4a40d62762ac034a201a9e922cc1c7efaf360cc307b0bed485102cdc
• Download URL:
  https://stacks.cdc.gov/view/cdc/190290/cdc_190290_DS1.pdf
• File Type:
  [PDF - 243.34 KB ]