The Comparative Immunotoxicity of Five Selected Compounds Following Developmental or Adult Exposure

Details

• Personal Author:
  Chen DH ; Dietert R ; King M ; Luebke RW ; Luster MI ; Yang Y
• Description:
  It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younger ages. Although not established absolutely, it is generally believed that development constitutes a period of increased immune system susceptibility to xenobiotics, since adverse effects may occur at lower doses and/or immunomodulation may be more persistent, thus increasing the relative risk of xenobiotic exposure to the immunologically immature organism. To address this issue, a brief overview of immune maturation in humans is provided to demonstrate that functional immaturity alone predisposes the young to infection. Age-dependent differences in the immunotoxic effects of five diverse compounds, diethylstilbestrol (DES), diazepam (DZP), lead (Pb), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and tributyltin oxide (TBTO), which have undergone adult and developmental immunotoxicity testing in rodents, are then reviewed, as are human data when available. For all five chemicals, the developing immune system was found to be at greater risk than that of the adult, either because lower doses produced immunotoxicity, adverse effects were more persistent, or both. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Immune System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Age-factors Age-groups Diseases Humans Immune-reaction Immune-system-disorders Immunotoxins Risk-analysis Risk-factors
• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-26
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20029231
• Citation:
  J Toxicol Environ Health B 2006 Jan-Feb; 9(1):1-26
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; Lead (CAS RN 7439-92-1) ; Tributyltin oxide (CAS RN 56-35-9)
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3a291766ca947564e12951fb30ba58c562b229d4c12c1319859224efc8c8582b58f9099c0474b41e61daca1ad8eda630a16c9db36dc5da13b0856724f11f6287
• Download URL:
  https://stacks.cdc.gov/view/cdc/190264/cdc_190264_DS1.pdf
• File Type:
  [PDF - 200.96 KB ]