A Common Polymorphism in XRCC1 as a Biomarker of Susceptibility for Chemically Induced Genetic Damage

Details

• Personal Author:
  Brandt-Rauf PW ; Li Y ; Marion MJ ; Rundle A
• Description:
  We have recently demonstrated a significant dose-response relationship between vinyl chloride exposure and mutant p53 biomarkers in humans. The aim of this study was to examine a common polymorphism in the DNA repair gene XRCC1 as a potential biomarker of susceptibility modifying this relationship, consistent with the known mechanism of production of p53 mutations via vinyl chloride-induced etheno-DNA adducts, which are repaired by XRCC1. A cohort of 211 French vinyl chloride workers were genotyped for the XRCC1 codon 399 polymorphism (CGG>CAG; Arg>Gln). Among the homozygous Arg-Arg individuals, 34% were biomarker positive compared with 47% in the heterozygous Arg-Gln individuals (adjusted odds ratio 1.73, 95% CI0.93-3.22) and 66% in the homozygous Gln-Gln individuals (adjusted odds ratio 3.95, 95% CI 1.68-9.28), with a significant trend for increasing Gln allele dosage (p=0.002). These preliminary results suggest that a common polymorphism in a DNA repair gene can be an important biomarker of susceptibility for chemically induced genetic damage. [Description provided by NIOSH]
• Subjects:
  Biomarkers DNA Genetics Occupational Exposure Occupational Health Safety
• Keywords:
  DNA-damage Dose-response Genes Genetic-disorders Genetic-factors Humans Mutation Occupational-exposure Workers
• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  408-414
• Volume:
  8
• Issue:
  5
• NIOSHTIC Number:
  nn:20029209
• Citation:
  Biomarkers 2003 Sep-Oct; 8(5):408-414
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Work Environment and Workforce: Special Populations
• Performing Organization:
  Department of Environmental Health Sciences, The Mailman School of Public Health, Columbia University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Biomarkers
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d2370825bf0ab7f84100e4d38707cb78b01483723d3bb6c4fbea669715971f630e58ea443c2eeb3a4231ea83ef07cf72c403563cf3c515c646be295b8eb8e3a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/190244/cdc_190244_DS1.pdf
• File Type:
  [PDF - 243.62 KB ]