Equilibrium Water Sorption in Human Stratum Corneum

Details

• Personal Author:
  Barai ND ; Kasting GB
• Description:
  The water content of the stratum corneum (SC) is a key factor in skin barrier homeostasis; it is intimately related to both skin condition and skin permeability. Studies of water uptake in excised human SC show strong similarities and allow characterization of the equilibrium SC water sorption isotherm in terms of widely used theoretical models. At low water activities, SC water sorption resembles that in other keratinized tissues (i.e., wool and horn), whereas at high water activities, it resembles that in polymeric hydrogels. In this paper, theoretical water sorption models [Brunauer-Emmett-Teller (BET), D'Arcy-Watt, and Frenkel-Halsey-Hill] are fit to the combined human SC water sorption data from our laboratories and others. Each of these models provides a satisfactory description of the equilibrium water content of human SC over the water activity range 0.03-1.0. An accompanying paper discusses the implications of SC water sorption on water mobility in corneocytes and on SC permeability. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Occupational Health Safety Skin Skin Absorption Water Purification
• Keywords:
  Humans In-vitro-study Metabolism Models Physiology Skin-absorption Water-analysis
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  92
• Issue:
  8
• NIOSHTIC Number:
  nn:20029201
• Citation:
  J Pharm Sci 2003 Aug; 92(8):1624-1631
• Contact Point Address:
  Gerald B. Kasting, College of Pharmacy, The University of Cincinnati, PO Box 670004, Cincinnati, Ohio 45267-0004, USA
• Email:
  Gerald.Kasting@uc.edu
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df0724948a3a96eba09af924099309a7414aabd71ab3960eeb1ddd5deb491f387b18dce98c5d42afae06fea0ba5f012abfba8aaab12b2be98799b5fa74288ec0
• Download URL:
  https://stacks.cdc.gov/view/cdc/190238/cdc_190238_DS1.pdf
• File Type:
  [PDF - 124.51 KB ]