Correlates of Oxidative Stress and Free-Radical Activity in Serum from Asymptomatic Shipyard Welders

Details

• Personal Author:
  Castranova, Vincent ; Han SG ; Kashon ML ; Kim Y ; Pack DL ; Vallyathan V
• Description:
  Oxidative stress is believed to play a key role in the development of welding-induced disease. This study investigated the effects of welding fume exposure on correlates of oxidative stress in the serum of asymptomatic shipyard welders. Blood samples from 197 male welders and 150 unexposed male office workers were analyzed for manganese and lead. Serum was assayed for protein, albumin, total antioxidant status (TAS), manganese superoxide dismutase (Mn-SOD), aconitase, glutathione peroxidase (GPx), heat shock protein 70, isoprostane, and reactive oxygen species, using electron spin resonance and chemiluminescence. Comparisons between welders and control subjects on biomarkers of oxidative stress were made, and evaluated for the effects of age and smoking. Associations between blood levels of manganese and lead and biomarkers were also explored. Welding was associated with increases in serum protein, GPx, aconitase, TAS, and isoprostane levels compared with control subjects. These group differences were not altered by age or smoking. In welders and control subjects, age was significantly associated with changes in albumin, TAS, chemiluminescence, GPx, and Mn-SOD. In welders and control subjects, smoking resulted in a decrease in GPx, and in a significant interaction between smoking and chemiluminescence. There were significant correlations between manganese levels in welders' blood and chemiluminescence, GPx, and Mn-SOD, and between lead levels and albumin, TAS, GPx, and Mn-SOD.Conclusions: These results document that exposure to welding can cause changes in serum biomarkers of oxidative stress that may be valuable in clinical monitoring of disease development and in assessing whether further reduction of worker exposures is needed. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Blood Free Radicals Hematologic Tests Occupational Diseases Occupational Exposure Occupational Health Safety Ships Welding

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• Keywords:
  Age-factors Blood-analysis Blood-samples Blood-sampling Diseases Free-radicals Lipid-peroxidation Occupational-diseases Occupational-exposure Shipyard-industry Shipyard-workers Shipyards Welders Welding-industry

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• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  172
• Issue:
  12
• NIOSHTIC Number:
  nn:20029177
• Citation:
  Am J Respir Crit Care Med 2005 Dec; 172(12):1541-1548
• Contact Point Address:
  Val Vallyathan, Ph.D., NIOSH/CDC, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  vav1@cdc.gov
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a6509ead40977c18024399c4dcbb67051089f06ae2b97fdebd5ada8a738ef8b50e13930865d57859aec22466bb2832f231bfbd930f3c091171ddf7eb7e03b57a
• Download URL:
  https://stacks.cdc.gov/view/cdc/190221/cdc_190221_DS1.pdf
• File Type:
  [PDF - 176.66 KB ]