Genetic Factors and Asthma in Aluminum Smelter Workers

Details

• Personal Author:
  Arnaiz NO ; Checkoway, Harvey ; Daroowalla, Feroza ; Farin F ; Kaufman JD ; Quigley S
• Description:
  An asthma-like condition has been reported among aluminum smelter potroom workers. The pathophysiologic mechanisms and the causative agent involved are unknown. Inasmuch as gene polymorphisms are associated with asthma in the general population, the authors of this case-control study examined whether polymorphisms were associated with the development of potroom asthma. Genotyping was performed for the beta2-adrenoreceptor, high-affinity Ig (immunoglobulin) E receptor, and Tumor Necrosis Factor on potroom workers who developed a new asthma-like condition and on individuals who did not develop respiratory problems. No associations were found between potroom asthma case status and genotype. The asthma-like condition associated with potroom work remains poorly understood. Future investigations of genetic susceptibility and occupational asthma may provide pathophysiologic insights into these work-related conditions, but larger numbers of subjects will be required. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Asthma Asthma, Occupational Case Reports Genetics Metals Metal Workers Occupational Diseases Occupational Exposure Occupational Health Safety Workplace

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• Keywords:
  Aluminum-compounds Aluminum-industry Bronchial-asthma Case-studies Genetic-factors Occupational-diseases Occupational-exposure Smelters Smelting Workers Workplace-monitoring Workplace-studies

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• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-200
• Volume:
  58
• Issue:
  4
• NIOSHTIC Number:
  nn:20029135
• Citation:
  Arch Environ Health 2003 Apr; 58(4):197-200
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of Washington Department of Enviromental Health, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19970930
• Source Full Name:
  Archives of Environmental Health
• End Date:
  20010929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9fb2d1d3bc3f19374b28164bd4965a2ba7cb50fdfe3a0884638ca2cc1e215bbe45e5fc45494a13949f7adb62bba70259eec1b9a6327ca90ff4e90d4b1040996e
• Download URL:
  https://stacks.cdc.gov/view/cdc/190187/cdc_190187_DS1.pdf
• File Type:
  [PDF - 137.16 KB ]