Neuropathological Changes in Vibration Injury: An Experimental Study

Details

• Personal Author:
  Kolachalam RB ; Matloub, Hani S. ; Riley, Danny A. ; Sanger JR ; Yan JG ; Zhang LL
• Description:
  Vibration syndrome, a clinical condition arising from chronic use of vibrating tools, is associated with a spectrum of neurovascular symptoms. To date, only its vascular pathology has been extensively studied; we sought to determine what direct neurologic injury, if any, is caused by vibration. Hindlimbs of anesthetized rats were affixed to a vibrating platform 4 h a day for 7 days. Study animals were vibrated with set parameters for frequency, acceleration, velocity, and amplitude; control animals were not vibrated. On day 7, nerves were studied by light and electron microscopy. While light microscopy showed minimal histologic differences between vibrated (n=12) and control (n=12) nerves, electron microscopic changes were dramatic. Splitting of the myelin sheath and axonal damage (e.g., myelin balls and "finger ring") were consistently seen in both myelinated and nonmyelinated axons. Despite relatively short vibration, definite pathology was demonstrated, suggesting that vibration syndrome has a direct neurologic component. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Nervous System Nervous System Diseases Occupational Health Safety Vibration
• Keywords:
  Animal-studies Injuries Laboratory-animals Neuropathology Neurovascular-disorders Vibration-effects Vibration-exposure
• ISSN:
  0738-1085
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  71-75
• Volume:
  25
• Issue:
  1
• NIOSHTIC Number:
  nn:20028868
• Citation:
  Microsurgery 2005 Jan; 25(1):71-75
• Contact Point Address:
  Hani S. Matloub, Department of Plastic Surgery, 8700 Watertown Plank Road, Milwaukee, WI 53226
• Email:
  hmatloub@mcw.edu
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Microsurgery
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:077c63f13aa893a42730fa3669b5c372e5ddc1c113d961f99b17320a5dcb32f84b6be2ddb9a41915021b51859b9036803cb2b1f5cd3aeba319840aa83816dd06
• Download URL:
  https://stacks.cdc.gov/view/cdc/189964/cdc_189964_DS1.pdf
• File Type:
  [PDF - 248.72 KB ]