p53 Autoantibodies Predict Subsequent Development of Cancer

Details

• Personal Author:
  Brandt-Rauf PW ; Hemminki K ; Karjalainen A ; Koskinen H ; Li Y ; Pukkala E ; Shnaidman M ; Vainio H ; Ying Z
• Description:
  Because TP53 mutations can induce an immune response and can occur early in the carcinogenic process for some tumors, p53 autoantibodies may be useful biomarkers for risk of development of cancer. Using banked serum samples from an asbestosis cohort at high risk for cancer, we demonstrate for the first time a statistically significant relationship between p53 autoantibodies and the subsequent development of malignancy (hazard ratio [HR] = 5.5, 95% confidence interval [CI] = 2.8-10.9) with a positive predictive value of 0.76 and an average lead time to diagnosis of 3.5 years. p53 autoantibodies were also significantly associated with p53 alterations in the resultant tumors (kappa = 0.78, p = 0.01). [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Immune System Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: P53 Mutation Biomarker Cancer Cancer Risk Carcinogenesis Carcinogenicity Immune Reaction Predictive Value Risk Analysis Risk Factors Tumors

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• ISSN:
  0020-7136
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  157-160
• Volume:
  114
• Issue:
  1
• NIOSHTIC Number:
  nn:20028856
• Citation:
  Int J Cancer 2005 Mar; 114(1):157-160
• Contact Point Address:
  Paul W. Brandt-Rauf, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032
• Email:
  pwb1@columbia.edu
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Performing Organization:
  Columbia University Health Sciences
• Peer Reviewed:
  True
• Start Date:
  20020601
• Source Full Name:
  International Journal of Cancer
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3614420613bbf2b14a4c7389aea583860aa376505712c666e60ad15abf53852d293c2aa2f267518dfeabfb3c75aa873ad490d8949d61d29ad5a414aef06e121
• Download URL:
  https://stacks.cdc.gov/view/cdc/189955/cdc_189955_DS1.pdf
• File Type:
  [PDF - 341.87 KB ]