Metabolic Syndrome and Echocardiographic Left Ventricular Mass in Blacks – the Atherosclerosis Risk in Communities (ARIC) Study

Details

• Personal Author:
  Andrew, Michael E. ; Arnett DK ; Burchfiel CM ; Garrison RJ ; Jones DW ; Skelton TN ; Taylor HA Jr.
• Description:
  The metabolic syndrome has been associated with cardiovascular disease, but few studies have examined its relationship with subclinical measures such as echocardiographic left ventricular (LV) mass. This relationship is likely to be of particular importance in blacks, in whom both the metabolic syndrome and LV hypertrophy are common. Echocardiography, performed at 1 of 4 sites in the Atherosclerosis Risk in Communities (ARIC) Study, was used to assess LV dimensions in 1572 black women and men aged 49 to 75 years in 1993-1996. Participants were categorized by number of metabolic syndrome characteristics (hypertension, dyslipidemia [low HDL cholesterol or high triglycerides], and glucose intolerance). Age-adjusted mean LV mass indexed by height (g/m) increased in a stepwise gradient with increasing number of metabolic syndrome disorders (none, any 1, any 2, all 3) in both women and men (125.1, 143.9, 153.7, 169.3 and 130.5, 148.7, 160.8, 170.2, respectively; P<0.001, tests for trend). Associations were diminished slightly by adjustment for smoking, alcohol intake, and education; additional adjustment for waist circumference resulted in some attenuation, but associations remained statistically significant. Analyses focusing on components of LV mass revealed that posterior wall and interventricular septal thickness, but not LV chamber size, were significantly and independently associated in general with the number of metabolic syndrome disorders. Consistent with these findings, relative wall thickness was also associated with number of disorders. Associations were similar across age and central adiposity. Hypertension had a strong influence on LV mass with additional contributions from dyslipidemia and glucose intolerance; strong synergistic effects of the syndrome beyond its individual components were not observed. In this cross-sectional population-based study of black women and men, the degree of metabolic syndrome clustering was strongly related to LV mass and its wall thickness components. These associations are consistent with a possible influence of underlying factors such as insulin resistance or other vascular processes on myocardial thickening and not on chamber size. [Description provided by NIOSH]
• Subjects:
  Age Factors Cardiovascular Diseases Cardiovascular System Demography Energy Metabolism Lipids Occupational Health Race Factors Risk Assessment Risk Factors Safety Sex Characteristics

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• Keywords:
  Age-factors Cardiovascular-disease Demographic-characteristics Hypertension Metabolic-disorders Metabolic-study Racial-factors Risk-analysis Risk-factors Sex-factors
• ISSN:
  0009-7322
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; Mississippi ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  112
• Issue:
  6
• NIOSHTIC Number:
  nn:20028222
• Citation:
  Circulation 2005 Aug; 112(6):819-827
• Contact Point Address:
  Cecil M. Burchfiel, PhD, MPH, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 4020, Morgantown, WV 26505
• Email:
  cburchfiel@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Circulation
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ece66728d51616ee2e59126d04a0bb43a71cef5972b12746f3309962a4cc19a43d6334badeb13d67f52340a49817a3421c866a3da356dca985a6f1da0c6e5d8c
• Download URL:
  https://stacks.cdc.gov/view/cdc/189820/cdc_189820_DS1.pdf
• File Type:
  [PDF - 88.58 KB ]