NF-kB, a Pivotal Transcription Factor in Silica-Induced Diseases

Details

• Personal Author:
  Chen F ; Shi X
• Description:
  Inhalation of silica in a number of occupational settings can result in debilitating and costly lung disease. It is thought that the pathological replacement of functional lung tissue with fibrotic lesions in silica-induced lung disease is the result of chronic inflammation mediated by products of the silica-exposed alveolar macrophage. In particular, inflammatory cytokines, growth factors and reactive oxygen species have been implicated in many acute and chronic inflammatory lung diseases. Pharmacological intervention to modify the production of these mediators has been shown to ameliorate several of these disease processes. Recent studies have demonstrated that the production of these inflammatory mediators is altered as a result of the activation of nuclear factor-kB (NF-kB). NF-kB is a pivotal transcription factor activated by silica in macrophages and other types of lung cells. The understanding of how silica induces NF-kB activation and what signaling pathways are involved in this silica-induced NF-kB activation is important and should provide valuable new information related to both the etiology and potential treatment of silica-related lung diseases. This review summarizes the molecular mechanisms involved in silica-induced NF-kB activation and discusses the importance of NF-kB as a critical transcription factor in mediating silica-induced lung diseases. [Description provided by NIOSH]
• Subjects:
  Cytology Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Alveolar-cells Cancer Cell-damage Cytopathology Gene-mutation Lung-disease Lung-tissue Respiratory-system-disorders Silica-dusts
• ISSN:
  0300-8177
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  169-176
• Volume:
  234
• Issue:
  1
• NIOSHTIC Number:
  nn:20028117
• Citation:
  Mol Cell Biochem 2002 May; 234-235(1):169-176
• Contact Point Address:
  National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  Xshi@cdc.gov
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2002
• Performing Organization:
  Center to Protect Workers' Rights
• Peer Reviewed:
  True
• Start Date:
  19900928
• Source Full Name:
  Molecular and Cellular Biochemistry
• End Date:
  19970515
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:79a22e4a8e6b3bbc48894c43e518b14f52ca648b773bb29773acad86b7bf324a4c0a1a95be3158554d0ef582456d77912ad1e8696009ab832d70bc5a4d820f70
• Download URL:
  https://stacks.cdc.gov/view/cdc/189789/cdc_189789_DS1.pdf
• File Type:
  [PDF - 156.27 KB ]