Induction of Activator Protein-1 (AP-1) by Asbestos and the Inhibitory Effect of Aspirin

Details

• Personal Author:
  Ding M
• Description:
  The following chapter presents what might be an important advance in the treatment and prevention of asbestos-related cancers. Asbestos-induced AP-1 activation, in vitro and in vivo, provides some understanding of the cellular pathology leading to cancer and the mechanisms by which such growth might be inhibited. This chapter indicates that aspirin is just such an inhibitor of the regulating transcription factor AP-1. It suggests the pathways where searches could be made for possible therapeutic agents that might play an important role against asbestos-related malignancies. [Description provided by NIOSH]
• Subjects:
  Animals Antioxidants Asbestos Carcinogens Cells, Cultured Dust Environmental Monitoring Hazardous Substances Inorganic Chemicals Laboratories Neoplasms Occupational Health Respiratory Tract Diseases Safety

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• Keywords:
  Analytical-methods Analytical-processes Animal-studies Asbestos-dust Asbestos-fibers Asbestos-products Cancer Carcinogenesis Carcinogenicity Cell-cultures Cell-damage Cell-function Cellular-function Cellular-reactions Exposure-assessment Laboratory-animals Pulmonary-system-disorders Respiratory-system-disorders Statistical-analysis Toxic-effects Toxins

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• ISBN:
  0327101282
• Publisher:
  LEXIS Law Publishing
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  173-196
• Volume:
  20
• NIOSHTIC Number:
  nn:20028109
• Citation:
  Sourcebook on asbestos diseases - Volume. 20: asbestos exposure and disease control. Peters GA, Peters PJ, eds. Carlottesville, VA: LEXIS Law Publishing, 1999 Jan; 20:173-196
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Aspirin (CAS RN 50-78-2)
• Editor(s):
  Peters GA; Peters BJ
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  Sourcebook on asbestos diseases - Volume. 20: asbestos exposure and disease control
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a03e7e6e8c8b908adc17e4e8ef7bfc0c5f7c7c7a254bcea8757970e2c6f3c6e5283e370c77f2f384b08a1b47bf4f64d9f82e4edcc55508f9711b8ff4e40acf4
• Download URL:
  https://stacks.cdc.gov/view/cdc/189781/cdc_189781_DS1.pdf
• File Type:
  [PDF - 1.69 MB ]