Estimation of Rodent Airway Parameters Using a Two Chamber Plethysmograph

Details

• Personal Author:
  Frazer DG ; Friend KA ; Goldsmith WT ; McKinney WG ; Reynolds JS ; Stolarik BM
• Description:
  A system was developed to estimate airway parameters of rodents using a two chamber plethysmograph. Rodent respiration in a two chamber flow-flow plethysmograph was modeled as a second order system in the continuous time domain. The model was converted to the equivalent digital filter, and the animal respiratory signals fitted to the filter using a least squares technique. The filter coefficients were then used to calculate the rodent airway parameters. These parameters included the product of airway resistance and thoracic gas compliance, which is a measure of airway constriction. Another calculated parameter was the thermal time constant associated with the heating and cooling of inspired and expired room temperature air. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Animals Dust Environmental Monitoring Laboratories Lung Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Aerosol-particles Airborne-dusts Airborne-particles Airway-obstruction Alveolar-cells Analytical-methods Analytical-processes Animal-studies Exposure-assessment Laboratory-animals Particulate-dust Pulmonary-function-tests Pulmonary-system-disorders Respiratory-function-tests Respiratory-system-disorders

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• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Illinois ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  162-165
• NIOSHTIC Number:
  nn:20028097
• Citation:
  Proceedings of the 3rd International Workshop on Biosignal Interpretation, Chicago, IL, June 12-14, 1999. Chicago, IL: University of Illinois 1999 Jun; :162-165
• Email:
  jsr0@cdc.gov
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the 3rd International Workshop on Biosignal Interpretation, Chicago, IL, June 12-14, 1999
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24ea618e7ca7335a7501e5b701123b8ca84cf18177656ec97b7a32ab7fcd90208374012727f90600d4112c96f892a1c07f3811e24721559bc2b760f60c88b390
• Download URL:
  https://stacks.cdc.gov/view/cdc/189777/cdc_189777_DS1.pdf
• File Type:
  [PDF - 659.71 KB ]