Chemical-Induced Activation of Nuclear Transcription Factors and Their Regulation of Cytokine Secretion

Details

• Personal Author:
  Luster ML ; Luster ML
• Description:
  Non-immune cells from a variety of organs, including the liver, lung and skin, when targeted by toxic agents, secrete pro-inflammatory cytokines and chemokines which participate in pathological as well as repair processes. In particular, tumor necrosis factor alpha (TNF a) and certain members of the neutrophil chemoattractant family of chemokines (CXC), including interleukin-8, play major roles in these responses. This presentation will describe several organ model systems for toxicity including asbestor-induced lung disease, arsenic-induced skin toxicity and heavy metal-medicated hepatotoxicity which demonstrate cytokine participation. In addition to describing the nature of these responses, the molecular events responsible will be detailed. A common pathway responsible for cytokine induction in all of these systems involves chemical-medicated, cellular oxidative stress, which, in turn, activates nuclear transcription factors, such as NF-kB, NF-IL-6 and AP-1. Unraveling the complex mechanism associated with these events may provide novel opportunities for intervention. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Hazardous Substances Liver Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Skin Diseases Toxicology

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• Keywords:
  Dose-response Liver-cells Liver-damage Liver-disorders Lung-cells Lung-disease Lung-disorders Lung-irritants Neutrophils Skin-disorders Skin-exposure Skin-irritants Skin-sensitivity Skin-tests Toxic-materials Toxins

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  48
• NIOSHTIC Number:
  nn:20028036
• Citation:
  Toxicologist 1999 Mar; 48(1-S):366
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana
• Supplement:
  1-S
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b4a2f5590e1957c32b4f3b2d6c1caf3333370e47622a868949c89a1d0d151a5c6a0cc591e2e9919bfa6450d69e28eef483035e7eba146527e0e2e0726a20e841
• Download URL:
  https://stacks.cdc.gov/view/cdc/189744/cdc_189744_DS1.pdf
• File Type:
  [PDF - 172.44 KB ]