A Meta-Analysis of Studies Investigating the Effects of Lead Exposure on Nerve Conduction

Details

• Personal Author:
  Brightwell WS ; Chrislip DW ; Krieg EF
• Description:
  Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0 mu g/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver. [Description provided by NIOSH]
• Subjects:
  Accidents, Occupational Coal Coal Mining Mining Occupational Health Safety
• Keywords:
  Biological-effects Biological-factors Bloodborne-pathogens Cellular-function Cellular-reactions Chemical-properties Exposure-assessment Hepatotoxicity Lead-compounds Liver-cells Liver-function Models Nephrological-disorders Nephrotoxicity Nerve-function Nerve-tissue Nervous-system Nervous-system-function Physiological-factors Physiological-testing Physiology Statistical-analysis Toxic-effects

  More +
• ISSN:
  0340-5761
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  82
• Issue:
  8
• NIOSHTIC Number:
  nn:20034428
• Citation:
  Arch Toxicol 2008 Aug; 82(8):531-542
• Contact Point Address:
  Edward F. Krieg Jr, Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
• Email:
  erk3@cdc.gov
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  True
• Source Full Name:
  Archives of Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67f866788f69b80abc8824a65a74bb631a53a2af885d9bcf307090b68127038e7fa62e13c68bf6d029d7bb0ebd184d40ba3bfe9d638df67d3b69a24c40d95256
• Download URL:
  https://stacks.cdc.gov/view/cdc/189634/cdc_189634_DS1.pdf
• File Type:
  [PDF - 557.36 KB ]