A Biocompatible Medium for Nanoparticle Dispersion

Details

• Personal Author:
  Andrew M ; Castranova, Vincent ; Jefferson A ; Porter, Dale ; Schwegler-Berry D ; Sriram K ; Wolfarth M
• Description:
  Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a 'lung fluid mimic'. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Analytical-processes In-vitro-studies In-vivo-studies Nanotechnology
• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  144-154
• Volume:
  2
• Issue:
  3
• NIOSHTIC Number:
  nn:20034341
• Citation:
  Nanotoxicology 2008 Sep; 2(3):144-154
• Contact Point Address:
  Dale Porter, PhD, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV, 26505, USA
• Email:
  dporter@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61fa887d510d09a9bb42e59c16f7bda267401f245c1ce7278e97d6a78e987fc228a2fe31a8346c3a504f5c6c7694a2c85a6d33f770e61c275dff4143dc341541
• Download URL:
  https://stacks.cdc.gov/view/cdc/189584/cdc_189584_DS1.pdf
• File Type:
  [PDF - 439.81 KB ]