Pulmonary Surfactant Adsorption and the Expression of Silica Toxicity

Details

• Personal Author:
  Keane MJ ; Wallace WE
• Description:
  In the alveolar regions of the lung, the interface between the epithelial cells and the air within alveoli consists of an aqueous dispersion of materials collectively designated pulmonary surfactant. Particles of silica or any other material that are inhaled into this region do not directly contact cells or tissue; the first contact will be with the hypophase that forms the tissue/air interface. Thus, interaction with the surfactant must precede any physical or chemical surface interaction with lung cells. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Aluminum Silicates Dust Environmental Monitoring Fibrosis Irritants Lung Lung Diseases Occupational Health Particulate Matter Quartz Respiratory System Respiratory Tract Diseases Safety Silicon Compounds Silicon Dioxide Surface-Active Agents

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• Keywords:
  Adsorbents Airborne-dusts Airborne-particles Breathing Dust-exposure Dust-particles Exposure-assessment Fibrous-dusts Lung-disease Lung-irritants Particulate-dust Pulmonary-system-disorders Quartz-dust Respiratory-irritants Respiratory-system-disorders Silica-dusts Silicates Silicon-compounds Silicosis Surfactants

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• ISBN:
  9780849347092
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  271-281
• NIOSHTIC Number:
  nn:20034307
• Citation:
  Silica and silica-induced lung diseases. Castranova V, Vallyathan V, Wallace WE, eds. Boca Raton, FL: CRC Press, 1995 Dec; :271-281
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Editor(s):
  Castranova V; Vallyathan V; Wallace WE
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Source Full Name:
  Silica and silica-induced lung diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0068b5a91cd56ef11ccf74c1934d9f3e392f6d3c0e2e117f02e278e2b5086ed0c79ac21e6fdb2aaa86e0c9dabd41eef89badec95894007328366b4c691efd163
• Download URL:
  https://stacks.cdc.gov/view/cdc/189558/cdc_189558_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]