Prediction of the Rate of Uptake of Carbon Monoxide from Blood by Extravascular Tissues

Details

• Personal Author:
  Bruce EN ; Bruce MC ; Erupaka K
• Description:
  Uptake of environmental carbon monoxide (CO) via the lungs raises the CO content of blood and of myoglobin (Mb)-containing tissues, but the blood-to-tissue diffusion coefficient for CO (DmCO) and tissue CO content are not easily measurable in humans. We used a multicompartment mathematical model to predict the effects of different values of DmCO on the time courses and magnitudes of CO content of blood and Mb-containing tissues when various published experimental studies were simulated. The model enhances our earlier model by adding mass balance equations for oxygen and by dividing the muscle compartment into two subcompartments. We found that several published experimental findings are compatible with either fast or slow rates of blood-tissue transfer of CO, whereas others are only compatible with slow rates of tissue uptake of CO. We conclude that slow uptake is most consistent with all of the experimental data. Slow uptake of CO by tissue is primarily due to the very small blood-to-tissue partial pressure gradients for CO. [Description provided by NIOSH]
• Subjects:
  Blood Epidemiology Hematologic Tests Occupational Health Safety
• Keywords:
  Blood-analysis Blood-gas-analysis Blood-vessels Hemodynamics Mathematical-models Physiological-response Statistical-analysis Tissue-disorders Tissue-distribution
• ISSN:
  1569-9048
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  142-159
• Volume:
  161
• Issue:
  2
• NIOSHTIC Number:
  nn:20034215
• Citation:
  Respir Physiol Neurobiol 2008 Apr; 161(2):142-159
• Contact Point Address:
  Eugene N. Bruce, Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070
• Email:
  ebruce@uky.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of Kentucky
• Peer Reviewed:
  True
• Start Date:
  20060701
• Source Full Name:
  Respiratory Physiology & Neurobiology
• End Date:
  20090630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7e6628aa66d571e77ee1ce1c1864e49326d3bd3d94355e76c680ddcb5c5be085e37deb8bf9a5d284327869988629fdea8bd49479dc36c9d0ea0dd4c203ff4a78
• Download URL:
  https://stacks.cdc.gov/view/cdc/189524/cdc_189524_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]