Irritancy and Sensitization Potential of Glyoxylic Acid

Details

• Personal Author:
  Anderson, Stacey E. ; Ham JE ; Munson AE
• Description:
  Glyoxylic acid, a small dicarboxylic acid, has been detected at measurable levels in the atmosphere and is suspected to be present in indoor air environments. It is generated through the ozonolysis of several high volume production compounds that are commonly found indoors. Glyoxylic acid was tested in a combined irritancy and local lymph node assay (LLNA). It tested positive in the LLNA with an EC3 value of 5.05%. Significant increases were observed in the B220(+) cell population in the draining lymph nodes. No changes were identified in the IgE(+)B220(+) cell population in the draining lymph nodes or total serum IgE levels; this suggests that glyoxylic acid functions as a T-cell-mediated contact sensitizer. Exposure to volatile organic compounds (VOC), similar to glyoxylic acid, emitted from building materials, cleaning formulations or other consumer products, and /or indoor chemistry have been linked to adverse health effects. These results may provide an explanation for some of adverse health effects associated with indoor air exposure. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Chemistry Construction Industry Construction Materials Environmental Health Hazardous Substances Hypersensitivity Occupational Health Risk Assessment Risk Factors Safety Surveys And Questionnaires

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• Keywords:
  Aerosol-particles Air-contamination Air-quality Chemical-analysis Chemical-composition Chemical-hypersensitivity Cleaning-compounds Construction-materials Health-hazards Health-surveys Indoor-air-pollution Indoor-environmental-quality Risk-analysis Risk-factors Sensitization

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• ISSN:
  1547-691X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  93-98
• Volume:
  5
• Issue:
  2
• NIOSHTIC Number:
  nn:20034207
• Citation:
  J Immunotoxicol 2008 Apr-Jun; 5(2):93-98
• Contact Point Address:
  Dr. Stacy E. Anderson, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505
• Email:
  sanderson4@cdc.gov
• CAS Registry Number:
  Glyoxylic acid (CAS RN 298-12-4)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Immunotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:abab3c651013c528fd063ac29d57abb7e5da4fb1a1846dff08b8e869b9487a5ac03fb34b39fb13fb9cf2c47e002e00b54d1ff751894533e9cd5e3db19d4855fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/189521/cdc_189521_DS1.pdf
• File Type:
  [PDF - 250.54 KB ]