Tumor Promoting or Tumor Suppressing of NF-kB, a Matter of Cell Context Dependency

Details

• Personal Author:
  Beezhold K ; Castranova, Vincent ; Chen F
• Description:
  Nuclear factor-kappa B (NF-kappa B) and its activating signaling pathways are critical regulators for cell lineage development, growth, differentiation, apoptosis, and tumorigenic transformation. As one of the most important transcription factors, NF-kappa B has been implicated in the transcriptional upregulation of a number of cytokines, adhesion molecules, growth factors, oncogenes, antiapoptotic proteins, some proapoptotic factors, and even certain viral genes. The role of NF-kappa B on tumor promoting has been well-documented in the past two decades. However, during the past few years, a considerable number of studies suggested that NF-kappa B and its activating signaling molecules may act as tumor suppressors under some circumstances. Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Cell-biology Cell-differentiation Cell-function Cell-metabolism Cell-transformation Cellular-function Cellular-reactions Nuclear-properties Oncogenesis Oncogenic-agents Oncogenicity Tumor-inhibition

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• ISSN:
  0883-0185
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  183-204
• Volume:
  27
• Issue:
  4
• NIOSHTIC Number:
  nn:20034122
• Citation:
  Int Rev Immunol 2008 Jul; 27(4):183-204
• Contact Point Address:
  Fei Chen, Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
• Email:
  LFD3@cdc.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  International Reviews of Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d824fb9399450624f57bd931ebe96d03519874a3f6eeb7ea7acdddbdce8d8beb8fc1e6ca4f9b3408bb3cd1ef55fea080cd232e85ed80ec7454ddb91dc6757f3c
• Download URL:
  https://stacks.cdc.gov/view/cdc/189488/cdc_189488_DS1.pdf
• File Type:
  [PDF - 5.54 MB ]