Regulation of Vascular Reactivity in Scleroderma: New Insights into Raynaud’s Phenomenon

Details

• Personal Author:
  Flavahan NA
• Description:
  Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma. [Description provided by NIOSH]
• Subjects:
  Accident Prevention Accidents Coal Coal Mining Engineering Mining Occupational Health Safety
• Keywords:
  Blood-vessels Enzymes Hormone-activity Hormones Muscle-cells Proteins Skin-exposure Skin-protection Vasoactive-agents Vibration-disease
• ISSN:
  0889-857X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  81-87
• Volume:
  34
• Issue:
  1
• NIOSHTIC Number:
  nn:20033860
• Citation:
  Rheum Dis Clin North Am 2008 Feb; 34(1):81-87
• Contact Point Address:
  Nicholas A. Flavahan PhD, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205
• Email:
  nflavah1@jhmi.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Jonhs Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050801
• Source Full Name:
  Rheumatic Diseases Clinics of North America
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db33dbe5f847149db176d5e3fcbc48f5a16541fc7f6b8c004630b7abb99fa6f93c08b7c0bd4591de8072309166a3d6e513c08e853d0d8e6911a0f3af84cc0567
• Download URL:
  https://stacks.cdc.gov/view/cdc/189276/cdc_189276_DS1.pdf
• File Type:
  [PDF - 129.43 KB ]