The IPCS Collaborative Study on Neurobehavioral Screening Methods: V. Results of Chemical Testing

Details

• Personal Author:
  Becking GC ; Brightwell WS ; Cuomo V ; De Salvia MA ; Frantik E ; Gill MW ; Haggerty GC ; Hornychova M ; Kulig BM ; Lammers J ; Larsen JJ ; MacPhail RC ; McDaniel KL ; Moser VC ; Nelson BK ; Ostergaard G ; Tilson HA ; Winneke G
• Description:
  The IPCS Collaborative Study on Neurobehavioral Screening Methods was undertaken to determine the intra-and inter-laboratory reliability of a functional observational battery (FOE) and an automated assessment of motor activity in eight laboratories world-wide. Following the training phase and the conduct of proficiency studies in all laboratories, participants proceeded to test the effects of seven chemicals in both single dose and four-week repeated dosing scenarios. The chemicals studied were acrylamide, bisacrylamide, p,p'-DDT, lead acetate, parathion, toluene, and triethyl tin. Participants received coded samples from a common source. In order to judge the general utility of these procedures in a diversity of testing situations, laboratories conducted the studies under their standard conditions, using their choice of rat strain and test equipment Chemical doses and time of peak effect for acute testing were determined by each laboratory: these parameters were guile similar for some chemicals, but varied greatly for others. The results of the chemical tests indicated that while there was some variability in the data on specific endpoints, all laboratories detected and characterized the effects of all but one of the known neurotoxicants. The one exception (toluene) was probably due to other factors (e.g., dose level, route of administration) rather than lack of sensitivity of the test methods. This study provides extensive data regarding the use of neurobehavioral screening methods over a range of laboratory conditions as well as the reliability, sensitivity, and robustness of the tests to detect neurotoxic potential of chemicals. [Description provided by NIOSH]
• Subjects:
  Chemistry Hypersensitivity Laboratories Nervous System Occupational Health Safety
• Keywords:
  Autonomic-nervous-system Chemical-analysis Chemical-hypersensitivity Chemical-indicators Chemical-reactions Laboratory-animals Laboratory-techniques Laboratory-testing Measurement-equipment Nervous-system Neurological-reactions Neuromotor-activity Neuromotor-function Neuromotor-system Neurotoxic-effects Neurotoxicology Neurotoxins Physiological-measurements Statistical-analysis

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• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:20033822
• Citation:
  Neurotoxicology 1997 Jan; 18(4):969-1055
• Contact Point Address:
  VC Moser, US EPA, NTD, Division of Neurotoxicol, National Health & Environmental Effects Research Lab, MD-74B, Research Triangle Pk, NC 27711
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1) ; DDT (CAS RN 50-29-3) ; Lead diacetate (CAS RN 301-04-2) ; Parathion (CAS RN 56-38-2) ; Toluene (CAS RN 108-88-3)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5bdc82cddd72f493668285e6307c4b2f7c75ffa3f2de729348145ff3897e0bf8f45a51c68b604efe160530ac525da02cc16a71c9893a2218646bb4733d169e91
• Download URL:
  https://stacks.cdc.gov/view/cdc/189250/cdc_189250_DS1.pdf
• File Type:
  [PDF - 39.93 MB ]