Occupational Exposure to Pesticides and Risk of Adult Brain Tumors

Details

• Personal Author:
  De Roos AJ ; Inskip PD ; Rajaraman P ; Samanic CM ; Stewart PA ; Waters MA
• Description:
  The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations. [Description provided by NIOSH]
• Subjects:
  Agriculture Carcinogens Herbicides Insecticides Men Neoplasms Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Agricultural-industry Brain-disorders Brain-tumors Carcinogenicity Carcinomas Mathematical-models Pesticides-and-agricultural-chemicals Risk-factors Statistical-analysis Worker-health
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  167
• Issue:
  8
• NIOSHTIC Number:
  nn:20033719
• Citation:
  Am J Epidemiol 2008 Apr; 167(8):976-985
• Contact Point Address:
  Claudine M. Samanic, US Dept HHS, Division of Cancer Epidemiology & Genetics, NCI, NIH, 6120 Execut Blvd,Room 8003, Rockville, MD 20852
• Email:
  samanicc@mail.nih.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3c41b5150b17c7db0009940c1fe8527cf51d75b7e785bf74865fab618350ce50b34ea1b2cb67cce41e1d3ce024e14d230b31f07871744d072df44dd57f45cda8
• Download URL:
  https://stacks.cdc.gov/view/cdc/189184/cdc_189184_DS1.pdf
• File Type:
  [PDF - 105.24 KB ]