Captan Exposure and Evaluation of a Pesticide Exposure Algorithm Among Orchard Pesticide Applicators in the Agricultural Health Study

Details

• Personal Author:
  Alavanja MCR ; Andrews, Ronnee N. ; Deddens JA ; Hines CJ ; Jaycox, Larry B. ; Striley CAF
• Description:
  Pesticide exposure assessment in the Agricultural Health Study (AHS) has relied upon two exposure metrics: lifetime exposure days and intensity-weighted lifetime exposure days, the latter incorporating an intensity score computed from a questionnaire-based algorithm. We evaluated this algorithm using actual fungicide exposure measurements from AHS private orchard applicators. Captan was selected as a marker of fungicide exposure. Seventy-four applicators from North Carolina and Iowa growing apples and/or peaches were sampled on 2 days they applied captan in 2002 and 2003. Personal air, hand rinse, 10 dermal patches, a pre-application first-morning urine and a subsequent 24-h urine sample were collected from each applicator per day. Environmental samples were analyzed for captan, and urine samples were analyzed for cis-1,2,3,6-tetrahydrophthalimide (THPI). Task and personal protective equipment information needed to compute an individual's algorithm score was also collected. Differences in analyte detection frequency were tested in a repeated logistic regression model. Mixed-effects models using maximum-likelihood estimation were employed to estimate geometric mean exposures and to evaluate the measured exposure data against the algorithm. In general, captan and THPI were detected significantly more frequently in environmental and urine samples collected from applicators who used air blast sprayers as compared to those who hand sprayed. The AHS pesticide exposure intensity algorithm, while significantly or marginally predictive of thigh and forearm captan exposure, respectively, did not predict air, hand rinse or urinary THPI exposures. The algorithm's lack of fit with some exposure measures among orchard fungicide applicators may be due in part to the assignment of equal exposure weights to air blast and hand spray application methods in the current algorithm. Some modification of the algorithm is suggested by these results. [Description provided by NIOSH]
• Subjects:
  Agriculture Fungi Fungicide, Industrial Insecticides Occupational Health Safety Urine Workplace
• Keywords:
  Agricultural-industry Agricultural-products Author Keywords: Agriculture Benomyl Captan Exposure Assessment Fungal-infections Fungicide Fungicides Mathematical-models Occupational Orchard Pesticide Pesticides-and-agricultural-chemicals Sprays Thiophanate-methyl Urinalysis Urine-chemistry Work-environment Worker-health

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• ISSN:
  0003-4878
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; New Jersey ; New York ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  153-166
• Volume:
  52
• Issue:
  3
• NIOSHTIC Number:
  nn:20033718
• Citation:
  Ann Occup Hyg 2008 Apr; 52(3):153-166
• Contact Point Address:
  Cynthia J.Hines, NIOSH, DSHEFS, 4676 Columbia Parkway, R-14, Cincinnati, OH 45226
• Email:
  chines@cdc.gov
• CAS Registry Number:
  Captan (CAS RN 133-06-2)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71c4a3db86a54525044d493a51448835105f009452b25ea4da68e7d61ea1e8bd1bfcb634bbd21fd7c57c4a615750df5b9e53b6698d99bbd2b80eb3aef4637ef0
• Download URL:
  https://stacks.cdc.gov/view/cdc/189183/cdc_189183_DS1.pdf
• File Type:
  [PDF - 132.50 KB ]