Elevated Serum IgE Concentrations in Systemic Lupus Erythematosus Are Related to History of Childhood Allergy, Asthma, and Hives

Details

• Personal Author:
  Biagini, Raymond E. ; Mackenzie BA ; Parks CG ; Sammons DL ; Smith JP
• Description:
  RATIONALE: Elevated serum IgE concentrations have sometimes been found in systemic lupus erythematosus (SLE) patients. Reasons for these findings and associations with clinical and autoantibody phenotype remain controversial. METHODS: Sera were obtained from 121 recently diagnosed SLE patients (American College of Rheumatology classification) and 114 population controls. ANAs (SS/A, SS/B, Sm, RNP, Jo-1, Scl-70, dsDNA, Centromere B, and Histone) were measured using a multiplexed ANA screen (AtheNA, Inverness). Total serum IgE was measured using an Immulite 2000 (Siemens). ANA results above 120 IU/ml and total IgE results above 100 IU/ml were considered positive. RESULTS: Mean total IgEwas non-significantly elevated in patients (mean 5 245 IU/ml, 95%Confidence Limits (CL) 94-396) compared with controls (89 IU/ml, 95% CL 61-117), and 30% of SLE patients were considered IgE positive compared with 22% of controls. Being IgE positive was not clearly related to prevalence of ANAs or specific SLE clinical features in medical records, or with report of currently active disease or measured C-reactive protein levels. Positive IgE was, however, significantly more common in patients with self-reported history of childhood onset asthma, hay fever or eczema (p 5 0.029), or ever having hives (p 5 0.043), with these independent associations persisting in race-adjusted multivariate models. CONCLUSIONS: These findings suggest elevated total IgE levels in cases may be related to history of allergic disease, but are not specifically related to SLE-specific ANAs, clinical features, or activity. Further studies should investigate whether shared risk factors could account for elevated IgE levels in SLE patients with history of allergic disease. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Irritants Occupational Health Respiratory Function Tests Respiratory Hypersensitivity Respiratory Tract Diseases Risk Assessment Risk Factors Safety
• Keywords:
  Allergens Allergic-disorders Allergic-reactions Immune-system-disorders Immunological-tests Respiratory-function-tests Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders Risk-analysis Risk-factors

  More +
• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  121
• Issue:
  2
• NIOSHTIC Number:
  nn:20033488
• Citation:
  J Allergy Clin Immunol 2008 Feb; 121(2)(Suppl 1):S228
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a1f4e7329cb9c67962b669324cea5fe64bc1bb7d81e38ec32179a68e80140063842c373b4375723f7c921d3b12ed2ac48f88acfdcb574f160cec80e045d9d016
• Download URL:
  https://stacks.cdc.gov/view/cdc/189038/cdc_189038_DS1.pdf
• File Type:
  [PDF - 38.44 KB ]