Elevated Serum IgE Concentrations in Systemic Lupus Erythematosus Are Related to History of Childhood Allergy, Asthma, and Hives

Details

• Personal Author:
  Biagini, Raymond E. ; Mackenzie BA ; Parks CG ; Sammons DL ; Smith JP
• Description:
  RATIONALE: Elevated serum IgE concentrations have sometimes been found in systemic lupus erythematosus (SLE) patients. Reasons for these findings and associations with clinical and autoantibody phenotype remain controversial. METHODS: Sera were obtained from 121 recently diagnosed SLE patients (American College of Rheumatology classification) and 114 population controls. ANAs (SS/A, SS/B, Sm, RNP, Jo-1, Scl-70, dsDNA, Centromere B, and Histone) were measured using a multiplexed ANA screen (AtheNA, Inverness). Total serum IgE was measured using an Immulite 2000 (Siemens). ANA results above 120 IU/ml and total IgE results above 100 IU/ml were considered positive. RESULTS: Mean total IgEwas non-significantly elevated in patients (mean 5 245 IU/ml, 95%Confidence Limits (CL) 94-396) compared with controls (89 IU/ml, 95% CL 61-117), and 30% of SLE patients were considered IgE positive compared with 22% of controls. Being IgE positive was not clearly related to prevalence of ANAs or specific SLE clinical features in medical records, or with report of currently active disease or measured C-reactive protein levels. Positive IgE was, however, significantly more common in patients with self-reported history of childhood onset asthma, hay fever or eczema (p 5 0.029), or ever having hives (p 5 0.043), with these independent associations persisting in race-adjusted multivariate models. CONCLUSIONS: These findings suggest elevated total IgE levels in cases may be related to history of allergic disease, but are not specifically related to SLE-specific ANAs, clinical features, or activity. Further studies should investigate whether shared risk factors could account for elevated IgE levels in SLE patients with history of allergic disease. Description provided by NIOSH
• Subjects:
  • Hypersensitivity
  • Irritants
  • Occupational Health
  • Respiratory Function Tests
  • Respiratory Hypersensitivity
  • Respiratory Tract Diseases
  • Risk Assessment
  • Risk Factors
  • Safety
• Keywords:
  • Respiratory-function-tests
  • Respiratory-hypersensitivity
  • Respiratory-irritants
  • Respiratory-system-disorders
  • Immunological-tests
  • Immune-system-disorders
  • Allergic-disorders
  • Allergic-reactions
  • Allergens
  • Risk-factors
  More +
• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  121
• Issue:
  2
• NIOSHTIC Number:
  nn:20033488
• Citation:
  J Allergy Clin Immunol 2008 Feb; 121(2)(Suppl 1):S228
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Supplement:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/189038/cdc_189038_DS1.pdf
• File Type:
  [PDF - 38.44 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a1f4e7329cb9c67962b669324cea5fe64bc1bb7d81e38ec32179a68e80140063842c373b4375723f7c921d3b12ed2ac48f88acfdcb574f160cec80e045d9d016